EARLY FUNCTIONAL & STRUCTURAL REPAIR IN MACAQUE STRABISMUS

这项研究的长期目标是揭示神经 解释婴儿每一种行为缺陷的机制 斜视(眼睛错位)，以及发育中的时间 它们是会发生的。该项目的具体目标是确定眼睛是否 在关键时期的早期调整可以修复这些行为 以及视觉皮质的结构性缺陷。新生的猕猴将会是 养大时戴着布拉德利博士为猴子设计的护目镜，这将 配戴棱镜，以诱导光学斜视。 斜视将在三个出生年龄(3岁)中的一个年龄进行修复 周、3个月、6个月)对应于“非常早”(3个月)， “平均”(12个月)和“晚期”(2年)斜视手术 孩子们。为该项目生成的三个假设在 普遍的预测是，眼睛越早重新排列， 复苏幅度就越大。资助NIH/NEI$38,505 12/01/98- 2002年11月30日发布无P51RR00165-38 98年1月1日-12月31日 区域灵长类研究中心

The long term goal of this research is to reveal the neural mechanisms that explain each of the behavioral deficits of infantile strabismus (eye misalignment), and the time in development at which they occur. The specific goal of the project is to determine if eye realignment early in the critical period can repair these behavioral and structural deficits of visual cortex. Newborn macaques will be reared wearing Dr. Bradley's goggles designed for monkeys, which will be fitted with prism lenses in order to induce optical strabismus. The strabismus will be repaired at one of three postnatal ages (3 weeks, 3 months, 6 months) corresponding to "very early" (3 months), "average" (12 months), and "late" (2 years) strabismus surgery in children. The three hypotheses generated for this project have in common the prediction that the earlier the realignment of the eyes, the greater the recovery. FUNDING NIH / NEI $38,505 12/01/98 - 11/30/02 PUBLICATIONS None P51RR00165-38 1/1/98 - 12/31/98 Yerkes Regional Primate Research Center