SURGICAL CORRECTION OF AN ARTERIO VENOUS FISTULA IN BABOON W/ CARDIAC ABNORMAL

心脏异常狒狒动静脉瘘的手术矫正

• 批准号: 6116367
• 负责人: JOHN T WEYHRICH
• 金额: $ 8.67万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6116367
• 关键词: Mammalia; Primates; cardiovascular system; surgery

During routine physical examination, a significant cardiac murmur (Grade V out of VI, holosystolic) was discovered in an adolescent female baboon. Subsequent work-up revealed palpable fremitus in the animal's right inguinal region, suggestive of an arterio-venous fistula (A-V shunt). Radiographs showed a grossly enlarged heart with possible associated pulmonary edema. Echocardiography confirmed that the heart was dilated, hypertrophic and hyperdynamic, due to volume overload from the A-V shunt. Ultrasound of the inguinal region confirmed the presence of a vascular communication between the femoral artery and vein (an A-V shunt). The origin of this baboon's shunt is unknown, but possible etiologies include a congenital abnormality or an iatrogenic cause subsequent to venipuncture. A surgical ligation of the shunt was performed and, since that time, the baboon's cardiac abnormalities have been monitored. While the animal's heart remains somewhat enlarged, the murmur is no longer present, heart function is adequate, the lungs appear to be clear and the inguinal fremitus is no longer palpable. The surgical correction of this A-V shunt appears to have been curative and the animal is now available for assignment to the colony breeding program.

在常规体格检查期间，在一只青春期雌性狒狒中发现了显著的心脏杂音（VI级中的V级，全收缩期）。随后的检查显示动物右侧腹股沟区可触及震颤，提示动静脉瘘（A-V分流）。 X线片显示心脏明显增大，可能伴有肺水肿。超声心动图证实，由于动静脉分流的容量超负荷，心脏扩张、肥大和动力亢进。 腹股沟区超声证实股动脉和静脉之间存在血管连通（动静脉分流）。 这只狒狒的分流的起源尚不清楚，但可能的病因包括先天性异常或静脉穿刺后的医源性原因。 进行了分流的手术结扎，从那时起，狒狒的心脏异常一直受到监测。 虽然动物的心脏仍然有些扩大，但杂音不再存在，心脏功能充足，肺部似乎清晰，腹股沟震颤不再明显。 该动静脉分流的手术矫正似乎具有治愈性，该动物现在可以分配到殖民地育种计划中。