SURGICAL CORRECTION OF AN ARTERIO VENOUS FISTULA IN BABOON W/ CARDIAC ABNORMAL

心脏异常狒狒动静脉瘘的手术矫正

• 批准号: 6277601
• 负责人: JOHN T WEYHRICH
• 金额: $ 7.23万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-01 至 1999-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6277601
• 关键词: Mammalia; Primates; cardiovascular system; surgery

During routine physical examination, a significant cardiac murmur (Grade V out of VI, holosystolic) was discovered in an adolescent female baboon. Subsequent work-up revealed palpable fremitus in the animal's right inguinal region, suggestive of an arterio-venous fistula (A-V shunt). Radiographs showed a grossly enlarged heart with possible associated pulmonary edema. Echocardiography confirmed that the heart was dilated, hypertrophic and hyperdynamic, due to volume overload from the A-V shunt. Ultrasound of the inguinal region confirmed the presence of a vascular communication between the femoral artery and vein (an A-V shunt). The origin of this baboon's shunt is unknown, but possible etiologies include a congenital abnormality or an iatrogenic cause subsequent to venipuncture. A surgical ligation of the shunt was performed and, since that time, the baboon's cardiac abnormalities have been monitored. While the animal's heart remains somewhat enlarged, the murmur is no longer present, heart function is adequate, the lungs appear to be clear and the inguinal fremitus is no longer palpable. The surgical correction of this A-V shunt appears to have been curative and the animal is now available for assignment to the colony breeding program.

在常规体检中，明显的心脏杂音 在一名青少年中发现了(VI中的V级，全收缩) 雌性狒狒。随后的检查显示可触摸到的弗莱米特氏菌 动物的右侧腹股沟区域，提示有动静脉 瘘管(房室分流术)。X光片显示心脏明显增大， 可能伴发肺水肿。超声心动图证实 心脏因体积增大、肥大和过度充血。 房室分流超载。腹股沟超声检查 已确认股骨之间存在血管交通 动脉和静脉(房室分流)。这只狒狒的分流的起源是 未知，但可能的病因包括先天性异常或 静脉穿刺术后的医源性原因。外科结扎术 进行了分流手术，从那时起，狒狒的心脏 已经对异常情况进行了监测。当动物的心脏还在的时候 稍有扩大，杂音不再存在，心功能 足够了，肺部看起来是干净的，腹股沟弗莱米特没有 更长的触觉。这种房室分流的外科矫正似乎 已经治愈，这只动物现在可以分配到 群体繁育计划。