CORE--TISSUE PROCUREMENT AND BANKING FACILITY

组织采购和银行设施（TPBF）是一个既定的CCSG- 在MDACC支持的核心设施，提供同行资助的基本 科学和临床研究人员在这个机构与人类肿瘤 已经被移除用于活检或治疗性切除的组织， 正在进行的研究项目。TPBF的职能是采购几乎所有 来自患者手术的病理性肿瘤组织，不用于 初步诊断，后续诊断研究，包括低温 储存以备将来临床随访。获得该肿瘤组织以 提供新鲜、无菌（如有要求）、表征良好的人类肿瘤 标本迅速（，1小时），以广泛的研究 参与几乎所有人类肿瘤研究的科学家。 将对核酸和 基因组分析的其他方法。TPBF，存储和 对肿瘤组织进行分类，用于疾病部位肿瘤计划，以及 冷冻保存，正在扩大到新的，专门指定的， 适当的空间，以提供更有效和包容的 肿瘤银行设施。扩大的银行设施不仅将 提供最先进的低温保存设施，但也将 包括一个交互式数据库，该数据库将提供 关于TPBF采购的肿瘤标本的信息。它还将 与其他机构数据库（医院，病理学， 流行病学等）它可以提供至关重要和重要的数据， 向客户提供相关信息，如机密性/安全性。 该提案的具体目标包括：1）提供一个灵活的 专业的组织采购资源， 快速递送新鲜获得的、充分表征的肿瘤组织 2）开发一个当代的，集中的 机构范围肿瘤组织采购和银行核心设施， 将提供与当前和预测的方法学兼容的组织 用于分析DNA、RNA和蛋白质以及其他分析方法; 3)开发一个交互式的、可访问的计算机数据库， 提供流行病学、家族史、患者治疗和患者 4）与现有的单个“卫星”协调， 目前，以计划方式管理和资助的组织库 在机构内运行。

The Tissue Procurement and Banking Facility (TPBF) is an established CCSG- supported core facility at the MDACC, that provides peer-funded basic science and clinical investigators at this institution with human tumor tissues that have been removed for biopsy or therapeutic resections, for on-going research projects. The TPBF functions to procure virtually all pathologic tumor tissue from patient procedures, that is not used for initial diagnosis, follow-up diagnostic studies, including cryogenically stored for future clinical follow-up. This tumor tissue is obtained to provide fresh, sterile (if requested), well-characterized human tumor specimens expeditiously (, 1 hour), to the wide spectrum of research scientists involved in virtually every type of human tumor investigation. Special preservation procedures will be instituted for nucleic acids and other methodologies for genomic analysis. The TPBF, that stores and triages tumor tissue for disease-site tumor programs, as well as cryopreservation, is being expanded into new, specifically designated and appropriate out-fitted space, to provide for more efficient and inclusive tumor banking facilities. The expanded banking facility will not only provide state-of-the-art cryopreservation facilities, but will also include an interactive database that will provide all pertinent information on tumor specimens procured by the TPBF. It will also interface with other institutional databases (hospital, pathology, epidemiology, etc.) that can provide vital and important data and other pertinent information to the searcher such as confidentiality/security. The specific aims of this proposal involve: 1) providing a flexible specialized tissue procurement resource providing for the efficient and expeditious delivery of freshly-obtained, well characterized tumor tissue to requesting investigators; 2) to develop a contemporary, centralized institution-wide tumor tissue procurement and banking core facility which will provide tissue compatible with current and predicted methodologies for analysis of DNA, RNA and protein as well as other methods of analysis; 3) to develop an interactive, accessible computer database which will provide epidemiology, family history, patient treatment and patient outcome and 4) to coordinate with existing individual "satellite", programmatically administered and funded tissue banks currently operational within the institution.