CORE--TISSUE PROCUREMENT AND BANKING FACILITY

核心——组织采购和银行设施

• 批准号: 6481855
• 负责人: RICHARD J FORD
• 金额: $ 25.41万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至 2002-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6481855
• 关键词: biomedical facility; cancer registry /resource; cell bank /registry; cryopreservation; histopathology; human tissue; neoplasm /cancer classification /staging; tissue /organ preservation

The Tissue Procurement and Banking Facility (TPBF) is an established CCSG- supported core facility at the MDACC, that provides peer-funded basic science and clinical investigators at this institution with human tumor tissues that have been removed for biopsy or therapeutic resections, for on-going research projects. The TPBF functions to procure virtually all pathologic tumor tissue from patient procedures, that is not used for initial diagnosis, follow-up diagnostic studies, including cryogenically stored for future clinical follow-up. This tumor tissue is obtained to provide fresh, sterile (if requested), well-characterized human tumor specimens expeditiously (, 1 hour), to the wide spectrum of research scientists involved in virtually every type of human tumor investigation. Special preservation procedures will be instituted for nucleic acids and other methodologies for genomic analysis. The TPBF, that stores and triages tumor tissue for disease-site tumor programs, as well as cryopreservation, is being expanded into new, specifically designated and appropriate out-fitted space, to provide for more efficient and inclusive tumor banking facilities. The expanded banking facility will not only provide state-of-the-art cryopreservation facilities, but will also include an interactive database that will provide all pertinent information on tumor specimens procured by the TPBF. It will also interface with other institutional databases (hospital, pathology, epidemiology, etc.) that can provide vital and important data and other pertinent information to the searcher such as confidentiality/security. The specific aims of this proposal involve: 1) providing a flexible specialized tissue procurement resource providing for the efficient and expeditious delivery of freshly-obtained, well characterized tumor tissue to requesting investigators; 2) to develop a contemporary, centralized institution-wide tumor tissue procurement and banking core facility which will provide tissue compatible with current and predicted methodologies for analysis of DNA, RNA and protein as well as other methods of analysis; 3) to develop an interactive, accessible computer database which will provide epidemiology, family history, patient treatment and patient outcome and 4) to coordinate with existing individual "satellite", programmatically administered and funded tissue banks currently operational within the institution.

组织采购和银行机制(TPBF)是一个既定的CCSG- 在MDACC支持的核心设施，提供同行资助的基本 该机构的科学和临床研究人员患有人类肿瘤 为活组织检查或治疗性切除而切除的组织 正在进行的研究项目。TPBF的职能是获得几乎所有 患者手术过程中的病理肿瘤组织，不用于 初步诊断、后续诊断研究，包括低温 储存起来以备将来的临床随访。这个肿瘤组织是为了 提供新鲜的、无菌的(如果要求)、特征良好的人类肿瘤 迅速(，1小时)采集样本，以进行广泛的研究 科学家们几乎参与了所有类型的人类肿瘤研究。 将制定特别的核酸保存程序和 基因组分析的其他方法。TPBF，即存储和 对肿瘤组织进行分类，用于疾病现场的肿瘤计划，以及 超低温保存，正在扩展到新的，特别指定和 适当的外部空间，以提供更高效和包容的空间 肿瘤银行设施。扩大后的银行设施不仅将 提供最先进的冷冻保存设施，但也将 包括一个交互式数据库，该数据库将提供所有相关 关于TPBF采购的肿瘤标本的信息。它还将 与其他机构数据库(医院、病理学、 流行病学等)可以提供至关重要的数据和其他 与搜索者相关的信息，如机密性/安全性。 这项提议的具体目标包括：1)提供灵活的 专门的组织采购资源，为高效和 快速运送新获得的、特征良好的肿瘤组织 请求调查人员；2)开发一种当代的、集中的 机构范围内的肿瘤组织采购和银行核心设施 将提供与当前和预测的方法兼容的组织 用于DNA、RNA和蛋白质的分析以及其他分析方法； 3)开发一个交互式、可访问的计算机数据库，该数据库将 提供流行病学、家族病史、患者治疗和患者 结果和4)与现有的个人“卫星”协调， 目前以程序化管理和资助的组织库 在机构内部运作。