CORE--TISSUE PROCUREMENT AND BANKING FACILITY

核心——组织采购和银行设施

• 批准号: 6352700
• 负责人: RICHARD J FORD
• 金额: $ 25.41万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-18 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6352700
• 关键词: biomedical facility; cancer registry /resource; cell bank /registry; cryopreservation; histopathology; human tissue; neoplasm /cancer classification /staging; tissue /organ preservation

The Tissue Procurement and Banking Facility (TPBF) is an established CCSG- supported core facility at the MDACC, that provides peer-funded basic science and clinical investigators at this institution with human tumor tissues that have been removed for biopsy or therapeutic resections, for on-going research projects. The TPBF functions to procure virtually all pathologic tumor tissue from patient procedures, that is not used for initial diagnosis, follow-up diagnostic studies, including cryogenically stored for future clinical follow-up. This tumor tissue is obtained to provide fresh, sterile (if requested), well-characterized human tumor specimens expeditiously (, 1 hour), to the wide spectrum of research scientists involved in virtually every type of human tumor investigation. Special preservation procedures will be instituted for nucleic acids and other methodologies for genomic analysis. The TPBF, that stores and triages tumor tissue for disease-site tumor programs, as well as cryopreservation, is being expanded into new, specifically designated and appropriate out-fitted space, to provide for more efficient and inclusive tumor banking facilities. The expanded banking facility will not only provide state-of-the-art cryopreservation facilities, but will also include an interactive database that will provide all pertinent information on tumor specimens procured by the TPBF. It will also interface with other institutional databases (hospital, pathology, epidemiology, etc.) that can provide vital and important data and other pertinent information to the searcher such as confidentiality/security. The specific aims of this proposal involve: 1) providing a flexible specialized tissue procurement resource providing for the efficient and expeditious delivery of freshly-obtained, well characterized tumor tissue to requesting investigators; 2) to develop a contemporary, centralized institution-wide tumor tissue procurement and banking core facility which will provide tissue compatible with current and predicted methodologies for analysis of DNA, RNA and protein as well as other methods of analysis; 3) to develop an interactive, accessible computer database which will provide epidemiology, family history, patient treatment and patient outcome and 4) to coordinate with existing individual "satellite", programmatically administered and funded tissue banks currently operational within the institution.

组织采购和银行设施 (TPBF) 是一个已建立的 CCSG- MDACC 支持的核心设施，提供同行资助的基本设施 该机构的人类肿瘤科学和临床研究人员 为活检或治疗性切除而切除的组织， 正在进行的研究项目。 TPBF 的职能是采购几乎所有 来自患者手术的病理肿瘤组织，不用于 初步诊断、后续诊断研究，包括低温 存储以供将来的临床随访。获得该肿瘤组织是为了 提供新鲜、无菌（如果需要）、特征良好的人类肿瘤 迅速（1 小时）获取标本，进行广泛的研究 科学家几乎参与了所有类型的人类肿瘤研究。 将对核酸和核酸实行特殊保存程序 其他基因组分析方法。 TPBF，存储和 针对疾病部位肿瘤计划对肿瘤组织进行分类，以及 冷冻保存，正在扩展到新的、专门指定的和 适当的配备空间，提供更高效、更包容的 肿瘤银行设施。扩大的银行融资不仅将 提供最先进的冷冻保存设施，但也将 包括一个交互式数据库，它将提供所有相关的 有关 TPBF 采购的肿瘤标本的信息。它还将 与其他机构数据库（医院、病理学、 流行病学等）可以提供至关重要的数据和其他 与搜索者相关的信息，例如机密性/安全性。 该提案的具体目标包括：1）提供灵活的 专门的组织采购资源提供高效和 快速递送新鲜获得的、特征明确的肿瘤组织 向提出请求的调查人员； 2）建立现代的、集中的 机构范围内的肿瘤组织采购和银行核心设施 将提供与当前和预测方法兼容的组织 用于 DNA、RNA 和蛋白质分析以及其他分析方法； 3）开发一个交互式的、可访问的计算机数据库 提供流行病学、家族史、患者治疗和患者信息 结果和 4) 与现有的单独“卫星”协调， 目前按计划管理和资助的组织库 在机构内运作。