PREVALENCE AND PATTERN OF HEPATIC DYSFUNCTION FOLLOWING FONTAN PROCEDURE

Fontan 手术后肝功能障碍的患病率和模式

• 批准号: 6114940
• 负责人: MICHAEL R. NARKEWICZ
• 金额: $ 1.99万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6114940
• 关键词: clinical research; congenital heart disorder; hemodynamics; human subject; liver disorder; liver disorder diagnosis; liver function; noninvasive diagnosis; postoperative state

The Fontan procedure offers a means of palliating the hemodynamic derangements associated with some complex congenital heart lesions. It does so by utilizing systemic venous pressure to drive blood across the pulmonary capillary bed. The result, in most cases, is a chronically elevated systemic venous pressure. Although several authors have raised concerns about the long term effect of this systemic venous hypertension on the liver, no one has systemically evaluated hepatic function in patients who have undergone the Fontan procedure nor characterized the precise biochemical and physiologic abnormalities in these patients. We propose to determine in a cross sectional study the characteristics of hepatic blood flow (galactose clearance, doppler ultrasonography), and hepatic synthetic function (PT, ammonia, cholesterol, clotting factors) in patients who have undergone the Fontan procedure. In the second phase of this study, we will perform a longitudinal study to describe the changes in PT and galactose elimination over time post Fontan to determine if these tests may be useful in monitoring the development of hepatic dysfunction in these patients.

Fontan手术提供了一种缓解与某些复杂先天性心脏病病变相关的血流动力学紊乱的方法。 它通过利用体静脉压驱动血液穿过肺毛细血管床来实现。 结果，在大多数情况下，是一个慢性升高的体静脉压。 尽管几位作者提出了这种全身静脉高压对肝脏的长期影响的担忧，但没有人对接受Fontan手术的患者的肝功能进行系统评价，也没有人对这些患者的确切生化和生理异常进行表征。 我们建议在一项横断面研究中确定接受Fontan手术患者的肝血流量（半乳糖清除率，多普勒超声检查）和肝脏合成功能（PT，氨，胆固醇，凝血因子）的特征。 在本研究的第二阶段，我们将进行一项纵向研究，以描述Fontan治疗后PT和半乳糖消除随时间的变化，以确定这些检测是否可用于监测这些患者的肝功能障碍发展。