RAPID REVERSAL OF PSYCHOTIC MAJOR DEPRESSION USING RU 486

使用 RU 486 快速逆转精神性重度抑郁症

• 批准号: 6219384
• 负责人: ALAN F. SCHATZBERG
• 金额: $ 0.06万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6219384
• 关键词: clinical research; cognition disorders; corticosteroid receptors; cortisol; dosage; hormone regulation /control mechanism; human subject; human therapy evaluation; major depression; mental disorder chemotherapy; mifepristone

This study uses the glucocorticoid-receptor antagonist RU486 (mifepristone) to treat patients with psychotic major depression. It is hypothesized that these patients have elevated levels of cortisol which leads to a hyperdopaminergic state which in turn results in cognitive dysfunction and psychosis. There is evidence that high-dose mifepristone rapidly resolves psychotic major depression. Clinicals were begun in mid-1996 and continue, We have collected data on 5 psychotically depressed patients.

本研究使用糖皮质激素受体拮抗剂RU486（米非司酮）治疗精神病性抑郁症患者。据推测，这些患者的皮质醇水平升高，导致高多巴胺能状态，进而导致认知功能障碍和精神病。有证据表明，高剂量米非司酮可迅速缓解精神病性抑郁症。自1996年年中开始临床研究并持续进行，我们收集了5例精神抑郁症患者的资料。