HYPOTHALAMIC-PITUITARY-OVARIAN AXIS IN WOMEN WITH EPILEPSY

女性癫痫患者的下丘脑-垂体-卵巢轴

• 批准号: 6115032
• 负责人: MARTHA J MORRELL
• 金额: $ 4.03万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6115032
• 关键词: clinical research; epilepsy; female; female reproductive system disorder; fertility; hormone regulation /control mechanism; human subject; hypothalamic pituitary axis; menstrual cycle; ovary; sex behavior; sex behavior disorder; sex hormones

Women with epilepsy may be at risk for reproductive health dysfunctions, including menstrual irregularity, anovulation, polycystic ovarian syndrome, and disturbances in basal and pulsatile release of gonadotropins and ovarian steroids. This study will define reproductive health risks for women with epilepsy and determine the relative mechanistic contribution of epilepsy syndrome, seizure frequency and type, and of individual antiepileptic drugs (AEDs) used in monotherapy. Pituitary and gonodal hormones, ovulatory function and ovarian morphology, and luteal phase function/adequacy will be evaluated in women with one of three distinct epilepsy syndromes: (1) idiopathic primary generalized epilepsy (PGE), in which the cerebral cortex is structurally and functionally normal; (2) symptomatic, localization related epilepsy (LRE) of temporal lobe origin, in which there is a structural and /or function functional lesion within the temporal lobe; and (3) LRE of extratemporal lobe origin in which the epileptogenic region resides outside of the temporal lobe. These indices of reproductive functions will also be evaluated according to exposure to AEDs in monotherapy that either induce, inhibit, or do not alter the hepatic mixed-function cytochrome P 450 enzyme system. Women with LRE of temporal lobe origin are hypothesized to be preferentially at risk for reproductive health dysfunctions because, given the extensive input of lesion is likely to cause hypothalamic- pituitary axis sysfunction. In addition, AEDs which inhibit P450 will increase steroid hormone concentrations and may predispose to reproductive dysfunctions. The effects of temporal lobe epilepsy versus AEDs before and after surgical resection of a temporal lobe epileptogenic focus, after which seizures are likety to remit while AEDs are held constant. These findings will permit the clinician to select an AED which is least likely to compromise reproductive health for a given epilepsy syndrome, and will make it more likely that women with epilepsy and reproductive dysfunction are identified and appropriately treated.

患有癫痫的女性可能面临生殖健康功能障碍的风险， 包括月经不调、无排卵、多囊卵巢 综合征，以及基础释放和脉动性释放障碍 促性腺激素和卵巢类固醇。这项研究将定义生殖 女性癫痫患者的健康风险及其相关因素的确定 癫痫综合征、癫痫发作频率和癫痫发作的机制 以及单一疗法中使用的个别抗癫痫药物(AEDs)。 垂体和性腺激素、排卵功能和卵巢 形态和黄体期功能/充分性将在 患有以下三种不同癫痫综合征之一的女性：(1)特发性 原发性全身性癫痫(PGE)，其中大脑皮层 结构和功能正常；(2)症状、定位 起源于颞叶的相关性癫痫(LRE)，其中有一个 颞叶内的结构和/或功能损害； (3)起源于颞外叶的LRE，其中致痫 该区域位于颞叶之外。这些指数是 生殖功能也将根据暴露情况进行评估。 单一疗法中的AEDs，诱导、抑制或不改变 肝脏混合功能细胞色素P450酶系统。 患有颞叶LRE的女性被假设为 优先处于生殖健康功能障碍的风险中，因为， 鉴于病变的广泛输入可能会导致下丘脑- 脑垂体轴功能障碍。此外，抑制P450的AEDs将 增加类固醇激素浓度，可能会导致 生殖功能障碍。颞叶癫痫的影响 手术切除颞叶前后AEDs的比较 致痫灶，之后癫痫发作似缓解，而抗癫痫药 保持不变。这些发现将允许临床医生选择 最不可能损害生殖健康的AED 考虑到癫痫综合症，这将使患有癫痫的女性更有可能 癫痫和生殖功能障碍被识别并适当地 治疗过了。