REPRODUCTIVE FUNCTION IN WOMEN WITH EPILEPSY

患有癫痫的妇女面临着生殖健康方面的挑战， 影响他们的生活质量。 生育力降低，月经不排卵 周期，生殖内分泌失调，多囊卵巢和 在女性中， 患有癫痫 几乎没有定量数据可以确定 生殖功能障碍的发病率和类型，也没有机制， 功能障碍已被阐明。 提出了一系列对照、前瞻性研究来描述 癫痫女性生殖功能缺陷，并确定 功能障碍的机制。 这些研究将评估主观 性功能，刺激诱导的生理性唤起， 生殖内分泌状态和排卵充分性。 三组 女性癫痫（女性颞叶癫痫定位相关 颞叶起源（TLE），颞外叶定位相关癫痫 起源[ETLE]和原发性全身性癫痫[PGE]）和对照组 组将进行比较，以评估研究假设， 与其他类型的生殖障碍相比， 癫痫 第五组由候选人组成， 癫痫病灶的手术切除将在术前和术后进行检查， 术后，提供消融后生殖功能的洞察 抗癫痫药物（AED）变量的致痫灶 保持不变。 阐明性和生殖的频率和机制 内分泌失调的女性癫痫将有重要的 临床意义 了解性和内分泌的病因 女性癫痫患者的功能障碍将导致特定的治疗 策略，包括激素操纵和替代选择， AED 最终目标是教育卫生保健提供者， 女性癫痫患者的生殖健康问题 脸上 最后，性和生殖内分泌功能障碍 与癫痫相关的疾病可以作为一个模型， 以及调节生殖功能和行为的激素途径。

Women with epilepsy face challenges to their reproductive health which impact their quality of life. Reduced fertility, anovulatory menstrual cycles, reproductive endocrine disorders, polycystic ovaries and decreased sexual desire and arousability have been described in women with epilepsy. Little quantitative data is available to establish incidence and types of reproductive dysfunction, nor have mechanisms of dysfunction been elucidated. A series of controlled, prospective studies is proposed to characterize deficits in reproductive function in women with epilepsy, and to identify the mechanisms of dysfunction. These studies will evaluate subjective sexual function, stimulus-induced physiological sexual arousal, reproductive endocrine status, and ovulatory adequacy. Three groups of women with epilepsy (women with localization related epilepsy of temporal lobe origin [TLE], localization related epilepsy of extratemporal lobe origin [ETLE], and primary generalized epilepsy [PGE]) and a control group will be compared in order to assess the study hypothesis that TEL is more often associated with reproductive disorders than other types of epilepsy. A fifth group comprised of patients who are candidates for surgical removal of an epileptogenic focus will be examined pre-and post-surgery, providing insight into reproductive function after ablation of an epileptogenic focus with the antiepileptic drug (AED) variable remaining constant. Elucidating the frequency and mechanisms of sexual and reproductive endocrine dysfunctions in women with epilepsy will have important clinical implications. Understanding etiologies of sexual and endocrine dysfunctions in women with epilepsy will lead to specific therapeutic strategies, including hormonal manipulation and alternative selection of AEDs. The ultimate goal is to educate health care providers and consumers about the reproductive health issues that women with epilepsy face. Finally, the sexual and reproductive endocrine dysfunctions associated with epilepsy could serve as a model for understanding neural and hormonal pathways mediating reproductive function and behavior.