GLUCOSE AND LIPID METABOLISM IN NIDDM--EFFECTS OF VERY LOW CALORIE DIETS

NIDDM 中的葡萄糖和脂质代谢——极低热量饮食的影响

• 批准号: 6115178
• 负责人: RICHARD M CARROLL
• 金额: $ 2.94万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6115178
• 关键词: basal metabolism; clinical research; epinephrine; glucose clamp technique; glucose metabolism; hormone regulation /control mechanism; human subject; human therapy evaluation; insulin sensitivity /resistance; lipid metabolism; noninsulin dependent diabetes mellitus; nutrition related tag; obesity; reducing diet

Will examine the effects of very low calorie diets (VLCD) on glucose and lipid metabolism in patients with upper body obesity (UBO) and non- insulin-dependent diabetes mellitus (NIDDM). Patients will be placed on VLCD for 14 days, and metabolism studies will be performed at baseline, immediately after, and six wks following the diets. Insulin resistance will be evaluated by hyperinsulinemic euglycemic clamp. Effects on lipid metabolism will be evaluated by measuring lipid release following epinephrine.

将研究极低热量饮食（VLCD）对葡萄糖和 上半身肥胖（UBO）和非肥胖患者的脂质代谢 胰岛素依赖型糖尿病（NIDDM）。患者将被安排在 VLCD治疗14天，并在基线时进行代谢研究， 之后立即和饮食后六周。胰岛素抵抗 将通过高胰岛素正葡萄糖钳夹法进行评价。 对脂质的影响 代谢将通过测量脂质释放来评价， 肾上腺素