EFFECT OF LOW CALORIE DIETS ON GLUCOSE/LIPID METABOLISM IN NIDDM

低热量饮食对 NIDDM 葡萄糖/脂质代谢的影响

• 批准号: 6246341
• 负责人: RICHARD M CARROLL
• 金额: $ 2.71万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-01-06 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6246341
• 关键词: adipose tissue; clinical research; diabetes mellitus therapy; diet therapy; glucose metabolism; human subject; human therapy evaluation; lipid metabolism; noninsulin dependent diabetes mellitus; nutrition related tag; obesity; tumor necrosis factor alpha

This study will examine the effect of short term (14 day) very low calorie diet therapy (VLCD)(420 kCal/day) in patients with upper body obesity and NIDDM. Sensitivity to insulin will be evaluated by euglycemic hyperinsulinemic clamp with stable isotope tracer infusion and the sensitivity of adipose tissue to epinephrine will be studied before/after VLCD therapy. Adipose tissue TNF will be measured by Northern blot analysis of adipose tissue biopsies. We hypothesize VLCD therapy will increase sensitivity of adipose tissue to insulin, normalize sensitivity to epinephrine and reduce production of TNF alpha by adipose tissue.

本研究将检查短期（14天）非常低的影响 上半身患者的卡路里饮食疗法（VLCD）（420 kCal/天） 肥胖和NIDDM。将通过以下方式评价胰岛素敏感性： 稳定同位素示踪剂正葡萄糖高胰岛素钳夹术 研究脂肪组织对肾上腺素的敏感性 VLCD治疗前/后。 将通过以下方法测量脂肪组织TNF： 脂肪组织活检的北方印迹分析。 我们假设VLCD 治疗将增加脂肪组织对胰岛素的敏感性， 使对肾上腺素的敏感性正常化并减少TNF α的产生 由脂肪组织。