CORRELATION OF PLASMA LEVELS IN VWF WITH THE VWF ALLELE AND ABO BLOOD TYPE

VWF 血浆水平与 VWF 等位基因和 ABO 血型的相关性

• 批准号: 6114641
• 负责人: ROBERT R MONTGOMERY
• 金额: $ 2.68万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6114641
• 关键词: ABO(H) blood groups; DNA; alleles; blood chemistry; clinical research; family genetics; gene expression; genetic disorder; human subject; phenotype; polymerase chain reaction; von Willebrand factor; von Willebrand's disease

This study will evaluate the inheritance of the vWF alleles in families with known von Willebrand disease or reduced levels of plasma vWF by analysis of DNA through combined use of PCR technology and detection of VNTR. Identification and tracking to these alleles within families can determine if inheritance of the allele corresponds with phenotypic expression of disease.

本研究将评估vWF等位基因在家庭中的遗传 已知的血管性血友病或血浆vWF水平降低， 通过PCR技术和检测的联合使用， VNTR。对这些等位基因在家系中的识别和追踪， 确定等位基因的遗传是否与表型 疾病的表达。