GRAPEFRUIT JUICE ON NEW MICROEMULSION CYCLOSPORIN BIOAVAILABILITY IN HUMANS

葡萄柚汁对新型微乳环孢菌素在人体中的生物利用度

• 批准号: 6114749
• 负责人: DAVID I MIN
• 金额: $ 1.92万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6114749
• 关键词: clinical research; cyclosporines; cytochrome P450; drug metabolism; drug screening /evaluation; emulsions; fruit; gastrointestinal function; human subject; human therapy evaluation; liver function; nutrient drug interaction; nutrition related tag; pharmacokinetics

In this study the investigators will evaluate the relationship of a metabolic probe for cytochrome P450 3A activity to cyclosporine (CSA) pharmacokinetics. They will also evaluate the ratio of intestinal and hepatic CYP3A activity and will study the effect of grapefruit juice on CSA bioavailability using a new microemulsion formulation of cyclosporine in healthy volunteers.

在本研究中，研究者将评估a的关系