GRAPEFRUIT JUICE ON NEW MICROEMULSION CYCLOSPORIN BIOAVAILABILITY IN HUMANS

葡萄柚汁对新型微乳环孢菌素在人体中的生物利用度

• 批准号: 6245875
• 负责人: DAVID I MIN
• 金额: $ 1.92万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-02-01 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6245875
• 关键词: clinical research; cyclosporines; cytochrome P450; drug metabolism; drug screening /evaluation; emulsions; fruit; gastrointestinal function; human subject; human therapy evaluation; liver function; nutrient drug interaction; nutrition related tag; pharmacokinetics

In this study we will evaluate the relationship of a metabolic probe for cytochrome P450 3A activity to cyclosporine (CSA) pharmacokinetics. We will also evaluate the ratio of intestinal and hepatic CYP3A activity and will study the effect of grapefuit juice on CSA bioavailability using a new microemulsion formulation of cyclosporine in healthy volunteers.

在这项研究中，我们将评估代谢探针与 细胞色素P450 3A活性对环孢素(CsA)药代动力学的影响。我们 还将评估肠道和肝脏细胞色素P3A活性的比率和 将研究葡萄汁对CsA生物利用度的影响 健康志愿者环孢素微乳制剂的研究。