EFFECT OF HYPOESTROGENISM ON BONE MINERAL DENSITY IN MARMOSETS

目的确定雌性恒河猴是否经历了 卵巢摘除后或社交后骨密度降低 诱导低雌激素无排卵。结果慢性减少 雌激素导致骨密度(BMD)下降，并导致 在研究它的大多数物种中，骨质疏松症的增加。 在绒猴中，社会上从属的雌性经常成为 无排卵，并可能长期保持低雌激素血症 时间到了。为了确定绒猴是否可能拥有一种机制 保护他们免受有害的骨骼后果 雌激素减退症，我们检测了卵巢切除诱导的或 社会性雌激素减退对骨密度的影响。在骨密度方面没有差异 发现于卵巢完整的和卵巢切除的雌性之间，或在 占主导地位的和从属的雌性。一项纵向研究也未能证明 揭示卵巢切除对骨密度的影响。因此，绒猴可能拥有 一种独特的适应保护它们免受低雌激素诱导的骨 损失，并可能提供一种新的模式，调查和 治疗骨质疏松症。我们计划确认的未来方向和 扩大我们的初步调查结果，并开始调查 雌激素可能通过的生化和细胞机制 雌性绒猴的耗竭与骨质流失是脱钩的。关键词 双能X线骨密度仪，骨骼系统，骨质疏松 资助Saltzman，W.，C，FED，AG15621，62,000美元，NIH。出版物 首页--期刊主要分类--期刊细介绍--期刊题录与文摘--期刊详细文摘内容 1998年。常见的绒猴缺乏雌激素耗竭，骨质丢失。 更年期生物学国际研讨会，加利福尼亚州纽波特海滩。 [A]

OBJECTIVE To determine whether female marmosets undergo a reduction in bone mineral density following ovariectomy or socially induced hypoestrogenic anovulation. RESULTS Chronic reduction in estrogen causes a reduction in bone mineral density (BMD) and an increase in osteoporosis in most species in which it has been studied. In marmosets, socially subordinate females regularly become anovulatory and may remain hypoestrogenemic for extended periods of time. To determine whether marmosets might possess a mechanism to protect them from the deleterious skeletal consequences of hypoestrogenism, we examined the effect of ovariectomy-induced or socially induced hypoestrogenism on BMD. No differences in BMD were found between ovary-intact and ovariectomized females, or between dominant and subordinate females. A longitudinal study also failed to reveal any effects of ovariectomy on BMD. Thus, marmosets may possess a unique adaptation protecting them from hypoestrogenism-induced bone loss, and might provide a novel model for the investigation and treatment of osteoporosis. FUTURE DIRECTIONS We plan to confirm and extend our preliminary findings and to begin to investigate the possible biochemical and cellular mechanisms by which estrogen depletion is decoupled from bone loss in female marmosets. KEY WORDS dual-energy X-ray absorptiometry, skeletal system, osteoporosis FUNDING Saltzman, W., C, FED, AG15621, $62,000, NIH. PUBLICATIONS Colman, R.J., W. Saltzman, D.H. Abbott, J.W. Kemnitz, and N. Binkley. 1998. Lack of estrogen depletion bone loss in common marmosets. International Symposium on Biology of Menopause, Newport Beach, CA. [A]