Stress, Anxiety, and Paternal Behavior in Fathers
父亲的压力、焦虑和父亲行为
基本信息
- 批准号:8076323
- 负责人:
- 金额:$ 22.57万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-05-24 至 2013-04-30
- 项目状态:已结题
- 来源:
- 关键词:AcuteAddressAffectAnimal ModelAnxietyAttentionAversive StimulusBehaviorBehavioralBiological FactorsBiological ModelsBiologyBirthBrainBuffersCaliforniaCaringChildChild Abuse and NeglectChild CareChronicChronic stressCognitiveDevelopmentEmotionalEndocrineEventExhibitsFathersFemaleFoundationsFutureHormonalHormonal ChangeHormonesHumanInfant CareInvestigationLactationLeadMaintenanceMammalsMaternal BehaviorModelingMothersMusNeuropeptidesNeurosecretory SystemsOxytocinParenting behaviorPaternal BehaviorPeptidesPeromyscusPhysiologicalPlayPregnancyPreventionProlactinPsychopathologyPsychosocial FactorRegulationReproductionResearchRodentRoleSignal TransductionStressSystemTestingTimeUnemploymentVasopressinsWomanWorkabuse neglectacute stressbasebiological adaptation to stresschild physical abusefatherhoodinsightmalemaltreatmentmenneonatenoveloffspringphysical neglectpreventpsychosocialpublic health relevancerelating to nervous systemresponsestressor
项目摘要
DESCRIPTION (provided by applicant): Human fathers in many cultures provide a significant amount of child care and play important roles in the cognitive, emotional, and psychosocial development of their children. At the same time, fathers and father surrogates perpetrate a disproportionately large number of instances of severe physical child abuse and child neglect, often in association with high levels of stress or stress-related psychopathology. The factors contributing to child maltreatment by fathers have received surprisingly little attention; however, stress, associated with such factors as unemployment, financial hardship, and parenting difficulties, is thought to play a role. In mammalian mothers, including women, hormonal and neural changes associated with pregnancy, parturition, and lactation lead to reductions in stress-responsiveness, anxiety, and fearfulness, changes that are thought to facilitate the onset of maternal behavior and to buffer maternal care from inhibition by stress or anxiety. It is unknown whether fathers in biparental species undergo similar changes in stress-responsiveness and emotionality. The onset of paternal care in these species, however, is associated with altered activity of several hormone and neuropeptide systems that have been implicated in the regulation of the stress response and emotionality. We suggest, therefore, that these neuroendocrine changes may function to reduce anxiety, fearfulness, and stress-responsiveness in new fathers, thereby facilitating the onset and maintenance of paternal behavior and reducing the likelihood that paternal care will be inhibited under stressful or anxiogenic conditions. In the proposed research, we aim to identify both the effects of stress on paternal care and the effects of fatherhood on stress-responsiveness in a biparental rodent, the California mouse. Specifically, we propose to determine (1) whether paternal care is inhibited by acute and/or chronic stress, and (2) whether fatherhood alters behavioral, hormonal, and neural responses to acute and chronic stressors. These studies will provide unique insights into mammalian paternal care and ultimately may have implications for preventing abuse and neglect of human children by fathers.
PUBLIC HEALTH RELEVANCE: Many human fathers make important contributions to the care and development of their children; however, fathers and father surrogates are also responsible for a disproportionately large number of child physical abuse and neglect incidents, often under stressful or anxiogenic conditions. The proposed research will use a biparental rodent, the California mouse, as a model system to investigate how stress affects paternal care and, conversely, whether fatherhood influences males' behavioral, hormonal, and neural responses to stress. This research will substantially advance our understanding of the biology of paternal behavior in humans and other mammals, and may ultimately have implications for the prevention of child maltreatment by fathers.
描述(由申请人提供):在许多文化中,人类父亲提供大量的儿童保育,并在儿童的认知,情感和心理社会发展中发挥重要作用。与此同时,父亲和父亲代理人实施了大量严重的儿童身体虐待和忽视儿童的情况,往往与高度的压力或与压力有关的精神病理学有关。令人惊讶的是,导致父亲虐待儿童的因素很少受到关注;然而,与失业、经济困难和养育子女困难等因素有关的压力被认为发挥了作用。 在哺乳动物母亲中,包括女性,与怀孕、分娩和哺乳相关的激素和神经变化导致压力反应性、焦虑和恐惧的减少,这些变化被认为有助于母性行为的发生,并缓冲母性护理免受压力或焦虑的抑制。目前还不清楚双亲物种中的父亲是否在压力反应和情绪方面经历了类似的变化。然而,在这些物种中,父亲照顾的发生与几种激素和神经肽系统的活性改变有关,这些激素和神经肽系统与压力反应和情绪的调节有关。因此,我们认为,这些神经内分泌的变化可能会减少焦虑,恐惧,和压力反应在新的父亲,从而促进父亲的行为的发生和维持,并减少可能性,父亲的照顾将被抑制在压力或焦虑的条件下。 在这项研究中,我们的目标是确定压力对父亲照顾的影响和父亲身份对双亲啮齿动物(加州小鼠)压力反应的影响。具体来说,我们建议确定(1)是否父亲的照顾是抑制急性和/或慢性压力,(2)是否父亲改变行为,激素和神经反应的急性和慢性压力。这些研究将为哺乳动物的父亲护理提供独特的见解,并最终可能对防止父亲虐待和忽视人类儿童产生影响。
公共卫生关系:许多人类父亲对子女的照顾和发展做出了重要贡献;然而,父亲和父亲代理人也要对大量儿童身体虐待和忽视事件负责,这些事件通常是在压力或焦虑的情况下发生的。这项拟议中的研究将使用一种双亲啮齿动物,加州小鼠,作为一个模型系统来研究压力如何影响父亲的照顾,反过来,父亲身份是否会影响男性对压力的行为,激素和神经反应。这项研究将大大推进我们对人类和其他哺乳动物父亲行为生物学的理解,并可能最终对预防父亲虐待儿童产生影响。
项目成果
期刊论文数量(12)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Effect of reproductive status on hypothalamic-pituitary-adrenal (HPA) activity and reactivity in male California mice (Peromyscus californicus).
- DOI:10.1016/j.physbeh.2013.02.016
- 发表时间:2013-03-15
- 期刊:
- 影响因子:2.9
- 作者:Harris BN;Saltzman W
- 通讯作者:Saltzman W
Plasticity of the paternal brain: Effects of fatherhood on neural structure and function.
- DOI:10.1002/dev.22097
- 发表时间:2021-07
- 期刊:
- 影响因子:2.2
- 作者:Horrell ND;Acosta MC;Saltzman W
- 通讯作者:Saltzman W
Paternal responsiveness is associated with, but not mediated by reduced neophobia in male California mice (Peromyscus californicus).
- DOI:10.1016/j.physbeh.2012.05.012
- 发表时间:2012-08-20
- 期刊:
- 影响因子:2.9
- 作者:Chauke, Miyetani;de Jong, Trynke R.;Garland, Theodore, Jr.;Saltzman, Wendy
- 通讯作者:Saltzman, Wendy
Differences in placentophagia in relation to reproductive status in the California mouse (Peromyscus californicus).
加州小鼠(Peromyscus californicus)的胎盘吞噬差异与生殖状态的关系。
- DOI:10.1002/dev.21154
- 发表时间:2014
- 期刊:
- 影响因子:2.2
- 作者:Perea-Rodriguez,JuanP;Saltzman,Wendy
- 通讯作者:Saltzman,Wendy
Paternal Care in Biparental Rodents: Intra- and Inter-individual Variation.
- DOI:10.1093/icb/icx047
- 发表时间:2017-09
- 期刊:
- 影响因子:2.6
- 作者:W. Saltzman;B. Harris;T. D. de Jong;J. P. Perea-Rodríguez;Nathan D. Horrell;Meng Zhao;J. R. Andrew
- 通讯作者:W. Saltzman;B. Harris;T. D. de Jong;J. P. Perea-Rodríguez;Nathan D. Horrell;Meng Zhao;J. R. Andrew
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WENDY SALTZMAN其他文献
WENDY SALTZMAN的其他文献
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{{ truncateString('WENDY SALTZMAN', 18)}}的其他基金
ROLE OF CORTICOTROPIN-RELEASING FACTOR IN PRIMATE MATERNAL BEHAVIOR
促肾上腺皮质激素释放因子在灵长类动物母体行为中的作用
- 批准号:
8173089 - 财政年份:2010
- 资助金额:
$ 22.57万 - 项目类别:
Stress, Anxiety, and Paternal Behavior in Fathers
父亲的压力、焦虑和父亲行为
- 批准号:
7995074 - 财政年份:2010
- 资助金额:
$ 22.57万 - 项目类别:
THE ROLE OF CORTICOTROPIN-RELEASING FACTOR IN PRIMATE MATERNAL BEHAVIOR
促肾上腺皮质激素释放因子在灵长类动物母体行为中的作用
- 批准号:
7958766 - 财政年份:2009
- 资助金额:
$ 22.57万 - 项目类别:
THE ROLE OF CORTICOTROPIN-RELEASING FACTOR IN PRIMATE MATERNAL BEHAVIOR
促肾上腺皮质激素释放因子在灵长类动物母体行为中的作用
- 批准号:
7716442 - 财政年份:2008
- 资助金额:
$ 22.57万 - 项目类别:
CORTICOTROPIN-RELEASING FACTOR IN HORMONAL AND BEHAVIORAL RESPONSES TO STRESS
激素和行为应激反应中的促肾上腺皮质激素释放因子
- 批准号:
7349466 - 财政年份:2006
- 资助金额:
$ 22.57万 - 项目类别:
The Role of Corticotropin-Releasing Factor in Primate Maternal Behavior
促肾上腺皮质激素释放因子在灵长类动物母性行为中的作用
- 批准号:
7147462 - 财政年份:2006
- 资助金额:
$ 22.57万 - 项目类别:
The Role of Corticotropin-Releasing Factor in Primate Maternal Behavior
促肾上腺皮质激素释放因子在灵长类动物母性行为中的作用
- 批准号:
7267990 - 财政年份:2006
- 资助金额:
$ 22.57万 - 项目类别:
NEURAL MECHANISMS OF CORTISOL SUPPRESSION IN MARMOSETS
狨猴皮质醇抑制的神经机制
- 批准号:
7165704 - 财政年份:2005
- 资助金额:
$ 22.57万 - 项目类别:
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