MONITORING PARKINSONISM IN PATIENTS WITH COMPLEX PATTERNS OF RESPONSE

监测具有复杂反应模式的帕金森病患者

• 批准号: 6116923
• 负责人: JOHN G NUTT
• 金额: $ 3.13万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6116923
• 关键词: Parkinson's disease; antiparkinson drugs; clinical research; clinical trials; dihydroxyphenylalanine; drug adverse effect; drug screening /evaluation; human subject; human therapy evaluation; nervous system disorder chemotherapy; neurologic manifestations; pharmacokinetics

Parkinsonian patients treated chronically with levodopa may develop complex fluctuations of neurological symptoms. We will monitor patients' neurological signs and plasma levodopa hourly throughout the waking hours for two days to: 1. Determine if establishing the magnitude and pattern of fluctuating symptoms and signs leads to improved control and would be a cost effective service. 2. Explore unusual patterns of response for other clues to the pharmacokinetic and pharmacodynamic properties of levodopa.

帕金森病患者长期使用左旋多巴治疗可能会出现 神经系统症状的复杂波动。 我们将监测患者的 在整个清醒时间内每小时一次的神经系统体征和血浆左旋多巴 两天：1。确定是否确定了 波动的症状和体征导致改善控制，将是一个 成本效益的服务。 2.探索其他人不寻常的反应模式 左旋多巴的药代动力学和药效学特性的线索。