MONITORING PARKINSONISM IN PATIENTS WITH COMPLEX PATTERNS OF RESPONSE

监测具有复杂反应模式的帕金森病患者

• 批准号: 6116923
• 负责人: JOHN G NUTT
• 金额: $ 3.13万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6116923
• 关键词: Parkinson's disease; antiparkinson drugs; clinical research; clinical trials; dihydroxyphenylalanine; drug adverse effect; drug screening /evaluation; human subject; human therapy evaluation; nervous system disorder chemotherapy; neurologic manifestations; pharmacokinetics

Parkinsonian patients treated chronically with levodopa may develop complex fluctuations of neurological symptoms. We will monitor patients' neurological signs and plasma levodopa hourly throughout the waking hours for two days to: 1. Determine if establishing the magnitude and pattern of fluctuating symptoms and signs leads to improved control and would be a cost effective service. 2. Explore unusual patterns of response for other clues to the pharmacokinetic and pharmacodynamic properties of levodopa.

患有左旋多巴的帕金森氏症患者可能会发展 神经系统症状的复杂波动。 我们将监视患者 整个醒来的时间 两天为：1。确定是否建立 症状波动和体征会导致控制的改善，这将是 成本效益的服务。 2。探索其他其他反应模式 左旋多巴的药代动力学和药效学特性的线索。