CAN APOMORPHINE PRODUCE A LONG DURATION RESPONSE

阿扑吗啡可以产生长时间的反应吗

• 批准号: 6116979
• 负责人: JOHN G NUTT
• 金额: $ 3.13万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6116979
• 关键词: Parkinson's disease; apomorphine; brain disorder chemotherapy; clinical research; dihydroxyphenylalanine; drug interactions; human subject; human therapy evaluation; neuropharmacology

The long-duration response to levodopa in patients with Parkinson's disease is an important component of the therapeutic response. The mechanism of the LDR is unknown. We differentiate between pre- and postsynaptic mechanisms by detrmining if apomorphine, a postsynaptic dopamine agonist, will sustin LDR.

帕金森病患者对左旋多巴的长期疗效 疾病是治疗反应的重要组成部分。这个 LDR的机制尚不清楚。我们区分Pre和Pre 通过去除突触后突触中的阿朴吗啡来实现突触后机制 多巴胺激动剂，会暂停LDR。