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EFFICACY OF DOPAMINE D1 AGONIST ABT-431 IN PD PATIENTS WITH LEVODOPA DYSKINESIAS

EFFICACY OF DOPAMINE D1 AGONIST ABT-431 IN PD PATIENTS WITH LEVODOPA DYSKINESIAS
多巴胺 D1 激动剂 ABT-431 对患有左旋多巴运动障碍的 PD 患者的疗效
批准号：
6116972
负责人：
JOHN G NUTT
金额：
$3.13万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6116972
关键词：
Parkinson's disease abnormal involuntary movement antiparkinson drugs clinical research clinical trials dihydroxyphenylalanine dopamine agonists drug screening /evaluation human subject human therapy evaluation

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中文摘要
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英文摘要
This protocol will compare the effects of a selective dopamine D1 agonist (ABT-431) to intravenous levodopa in Parkinson's patients with dyskinesia. Patients with Parkinson's disease, a fluctuating response to levodopa and dyskinesia will receive single daily infusions of ABT-431 in various concentrations or intravenous levodopa on 5 consecutive days, under double-blind conditions. Parkinsonism will be scored with a clinical scring system (Unified Parkinson's Disease Rating Scale) and blood collected for pharmacokinetic.
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