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ACTG 382--DMP 266 IN COMBINATION WITH NELFINAVIR IN HIV INFECTED CHILDREN

ACTG 382--DMP 266 IN COMBINATION WITH NELFINAVIR IN HIV INFECTED CHILDREN
ACTG 382--DMP 266 与奈非那韦联合治疗 HIV 感染儿童
批准号：
6219851
负责人：
Stuart E Starr
金额：
$0.06万
依托单位：
CHILDREN'S HOSP OF PHILADELPHIA
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6219851
关键词：
AIDS therapy HIV infections antiAIDS agent antiviral agents child (0-11) clinical research clinical trials combination therapy drug screening /evaluation human subject human therapy evaluation pediatric AIDS pediatric pharmacology pharmacokinetics

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中文摘要
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英文摘要
ACTG 382 is a phase I/II, open-label study of a new antiretroviral drug combination (efavirenz plus nelfinavir) in children with HIV infection. This study evaluates this drug combination for its pharmacokinetics, safety, antiviral activity (as measured by changes in plasma HIV RNA level) and effects on immune reconstitution in children ages 3 months to 16 years of age. The treatment duration is 104 weeks. This multicenter study is nearing completion of accrual, and is currently open to accrual only for children in the youngest age cohort (3 months to 8 years of age). Preliminary data show favorable effects on suppression of viral load and acceptable tolerability for this drug combination.
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  • 财政年份：
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