课题基金 / 基金详情

K-MAG FACILITATED STONE FRAGMENT DISCHARGE DURING LITHOTRIPSY

K-MAG FACILITATED STONE FRAGMENT DISCHARGE DURING LITHOTRIPSY
K-MAG 在碎石过程中促进结石碎片排出
批准号：
6117552
负责人：
MARGARET S. PEARLE
金额：
$3.48万
依托单位：
UT SOUTHWESTERN MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6117552
关键词：
calcium citrates clinical research human subject lithotripsy magnesium nephrolithiasis oxalates potassium urinalysis

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中文摘要
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英文摘要
The objective of this study is to determine whether K-Mag treatment would alleviate "steinstrasse" (obstruction of the ureter with stone fragments) and reduce residual stone mass following extracorporeal piezoelectric lithotripsy. The proposal will test the hypothesis that K-Mag treatment would meet the above expectations, by raising urinary magnesium and citrate levels. The rise in these "inhibitors" in urine would prevent agglomeration of stone fragments. Moreover, the complexation of calcium by citrate and that of oxalate by magnesium may lead to a reduced stone mass. the above actions may be exaggerated by an increase in urinary pH occuring from K-Mag therapy.
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