K-MAG FACILITATED STONE FRAGMENT DISCHARGE DURING LITHOTRIPSY

K-MAG 在碎石过程中促进结石碎片排出

• 批准号: 6567683
• 负责人: MARGARET S. PEARLE
• 金额: $ 32.14万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-12-01 至 2002-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6567683
• 关键词: calcium; citrates; clinical research; human subject; lithotripsy; magnesium; nephrolithiasis; oxalates; potassium; urinalysis

The objective of this study is to determine whether K-Mag treatment would alleviate "steinstrasse" (obstruction of the ureter with stone fragments) and reduce residual stone mass following extracorporeal piezoelectric lithotripsy. The proposal will test the hypothesis that K-Mag treatment would meet the above expectations, by raising urinary magnesium and citrate levels. The rise in these "inhibitors" in urine would prevent agglomeration of stone fragments. Moreover, the complexation of calcium by citrate and that of oxalate by magnesium may lead to a reduced stone mass. the above actions may be exaggerated by an increase in urinary pH occuring from K-Mag therapy.

本研究的目的是确定K-MAg治疗 将缓解“Steinstrasse”(输尿管结石梗阻 碎石)和减少体外循环后的残余结石 压电碎石术。这项提议将检验这一假设 K-Mag治疗将达到上述预期，通过增加尿量 镁和柠檬酸盐的水平。尿液中这些“抑制物”的增加 可以防止石块结块。此外， 柠檬酸盐对钙的络合作用和镁对草酸盐的络合作用可 导致石块质量减少。上述行动可能被夸大了 K-Mag治疗引起尿液pH值升高。