DIALYSIS ADEQUACY IN CHILDREN ON PERITONEAL DIALYSIS

本研究的假设是，KT/V尿素或总肌酐清除率，这两种透析输送的指标，将与维持PD的儿童患者的预后相关。这将是一项前瞻性观察性研究，随访新患帕金森病的儿童24个月，每季度测量一次透析交付和结果。结果测量将回归到透析交付。预计至少有120名患者可以入组。为了正确测量KT/V尿素，将测量进入受试者的TBW。预计，这将允许阐明一个可预测的，可推广的关系之间的总身体水分和基本人体测量数据，特别是身高和体重，儿童PD。GCRC用于宏观受试者，使用H2018测量全身水分。Nair博士的实验室将测量所有中心所有参与者的总身体水分（即分析样本并计算总体重）。入职后随访24个月。很少有超过8-12个月的参保人。没有初步结果。

The hypothesis of this study is that KT/V urea or total creatinine clearance, both measures of dialysis delivery, will correlate with patient outcomes in children on maintenance PD. This will be a prospective observational study, following children new to PD for 24 months, with dialysis delivery and outcome measured quarterly. Outcome measures will be regressed against dialysis delivery. It is anticipated that at least 120 patients can be enrolled. In order to correctly measure KT/V urea, TBW will be measured in the subjects entered. It is anticipated that this will allow for the elucidation of a predictable, generalizable relationship between total body water and basic anthropometric data, specifically height and weight, in children on PD. GCRC used for macro subjects to measure total body water using H2018. Dr Nair's laboratory will measure total body water (i.e. analyze samples and calculate total body weight) on all enrollees in all centers. Follow-up from entry is 24 months. Few enrollees are yet past 8-12 months. No preliminary results.