DIALYSIS ADEQUACY IN CHILDREN ON PERITONEAL DIALYSIS

这项研究的假设是，KT/V尿素或总肌酐清除量，这两个衡量透析交付的指标，将与维持性PD儿童的预后相关。这将是一项前瞻性的观察性研究，追踪刚接触帕金森病24个月的儿童，每季度测量透析的交付和结果。结果指标将对透析交付进行倒退。预计至少有120名患者可以入选。为了正确测量KT/V尿素，将在输入的受试者中测量TBW。预计这将有助于阐明帕金森病儿童的全身水分和基本人体测量数据之间的可预测、可概括的关系，特别是身高和体重。GCRC用于宏观受试者使用H2018测量全身水分。奈尔博士的实验室将测量所有中心所有参与者的总体内水分(即分析样本并计算总体重)。入选后随访时间为24个月。很少有参与者超过8-12个月。没有初步结果。

The hypothesis of this study is that KT/V urea or total creatinine clearance, both measures of dialysis delivery, will correlate with patient outcomes in children on maintenance PD. This will be a prospective observational study, following children new to PD for 24 months, with dialysis delivery and outcome measured quarterly. Outcome measures will be regressed against dialysis delivery. It is anticipated that at least 120 patients can be enrolled. In order to correctly measure KT/V urea, TBW will be measured in the subjects entered. It is anticipated that this will allow for the elucidation of a predictable, generalizable relationship between total body water and basic anthropometric data, specifically height and weight, in children on PD. GCRC used for macro subjects to measure total body water using H2018. Dr Nair's laboratory will measure total body water (i.e. analyze samples and calculate total body weight) on all enrollees in all centers. Follow-up from entry is 24 months. Few enrollees are yet past 8-12 months. No preliminary results.