DIURNAL VERSUS NOCTURNAL INDUCTION OF LABOR

白天与夜间引产

• 批准号: 6264916
• 负责人: KENNETH K CHAN
• 金额: $ 0.1万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6264916
• 关键词: birth; circadian rhythms; clinical research; female; human pregnant subject; human subject; human therapy evaluation; women's health

Currently, in clinical obstetrics, 10-30% of pregnancies are induced for a variety of maternal and fetal indications ranging from post dates, deteriorating maternal condition, to social reasons. Most inductions are started in the morning using pitocin, the synthetic form of the hormone oxytocin, and infused for eight to ten hours. The failure rates of inductions range from 20-50%, resulting in multiple day trials and ultimately a Ceasarian section rate as high as 50%. Because there is a circadian rhythm in human labor such that spontaneous contractility and uterine sensitivity to oxytocin is maximal at night, we propose to compare the efficacy and duration of diurinal versus nocturnal induction of labor.

目前，在临床产科中，有10-30％的怀孕是针对各种母体和胎儿的适应症，从邮政日期，恶化孕产妇状况到社会原因。 大多数诱导均在早晨使用pitocin（激素催产素的合成形式）开始，并注入八到十个小时。 归纳的失败率范围为20-50％，导致多天试验，最终造成的ceasarian截面率高达50％。 由于人工劳动中有昼夜节律，因此自发性收缩力和对催产素的敏感性在夜间最大，因此我们建议比较二维与夜间劳动的疗效和持续时间。