AGING, TRAINING, AND SKELETAL MUSCLE BLOOD FLOW DURING EXERCISE

运动过程中的衰老、训练和骨骼肌血流

• 批准号: 6117367
• 负责人: MICHAEL J JOYNER
• 金额: $ 2.01万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6117367
• 关键词: aging; cardiovascular function; clinical research; exercise; human subject; muscle function; striated muscles

The aim of this study is to learn more about how age-related changes in the cardiovascular system affect the ability of humans to exercise with large and small muscle groups. Currently it is unclear if the reduced exercise capacity seen in humans as they age is a result of reduced maximal muscle blood flow or a reduction in cardiac output. In this study, the investigators will determine whether there is evidence to support either possibility. We made strong progress in the non-invasive aspects of this protocol and conducted studies that allowed us to determine the relationship between skeletal muscle mass and exercise tolerance in aging humans. We have also looked at the relationship between cardiac output, muscle mass, and the rise in oxygen uptake that occurs with exercise in aging humans. Additionally, we have initiated our invasive studies to better define the leg blood flow responses to exercise in aging humans. Data from this project has been used as a pilot study that has permitted Dr. David Proctor to submit a grant proposal to the NIH. The approaches used to stud exercise responses and use of exercise protocols in aging subjects have been expanded at Mayo as a result of this protocol.

这项研究的目的是更多地了解心血管系统中与年龄相关的变化如何影响人类与大小肌肉群一起锻炼的能力。目前尚不清楚人类随着年龄的增长而出现的运动量下降是由于最大肌肉血流量减少还是心输出量减少所致。在这项研究中，调查人员将确定是否有证据支持这两种可能性。我们在该方案的非侵入性方面取得了很大进展，并进行了一些研究，使我们能够确定骨骼肌量和老年人类运动耐量之间的关系。我们还观察了心输出量、肌肉质量和老年人类运动引起的摄氧量增加之间的关系。此外，我们已经启动了侵入性研究，以更好地确定老年人类对运动的腿部血流反应。该项目的数据已被用作先导性研究，允许David Proctor博士向NIH提交拨款提案。作为这一方案的结果，Mayo扩展了用于研究运动反应和老年受试者运动方案使用的方法。