ADVANCED SHORT COURSE

第二个高级短期课程，题为《建模与数据 应用Adapt II进行药代动力学和药效学分析“， 由Dargenio教授组织的会议将于1998年8月5日至6日在 美国国立卫生研究院。达吉尼奥教授将会是 由两名在使用Adapt包方面经验丰富的NCI科学家协助 (Steve Piscitelli博士和William Figg博士)。20多名NCI科学家 计划参加这次为期两天的会议，每位与会者 通过他们的个人笔记本电脑访问适配器。这个 短期课程将重点介绍Adapt软件包的使用 建模、仿真、参数估计和实验设计 在药物动力学和药效学方面。案例研究将是 介绍了ADAPT软件在实际工程中的应用 解决各种建模、评估和实验设计 有问题。案例研究涉及实际操作的计算机工作和意志 涵盖以下主题：药效学建模；贝叶斯 估计、最大似然与广义最小二乘 估计.多个输出模型的估计.抽样计划 设计；生理模型模拟；具有时滞的模型；以及 使用协变量进行建模。

The second Advance Short Course, entitled "Modeling and Data Analysis in Pharmacokinetics and Pharmacodynamics Using ADAPT II", organized by Professor D'Argenio will be held on August 5-6, 1998 at the National Institutes of Health. Professor D'Argenio will be assisted by two NCI scientists experienced in using the ADAPT Package (Dr. Steve Piscitelli and Dr. William Figg). Over 20 NCI scientists are scheduled to attend this two-day meeting, with each participant accessing ADAPT through their individual notebook computers. The Short Course will focus on the use of the ADAPT software packages for modeling, simulation, parameter estimation, and design of experiments in pharmacokinetics and pharmacodynamics. Case studies will be presented illustrating the application of the ADAPT software for solving a variety of modeling, estimation, and experiment design problems. The Case Studies involves hands-on computer work and will cover the following topics: pharmacodynamic modeling; Bayesian estimation, maximum likelihood and generalized least squares estimation; estimation with multiple output models; sample schedule design; physiological model simulation; models with time delays; and modeling with covariates.