ADVANCED SHORT COURSE

第二期高级短期课程，题为“建模和数据 使用ADAPT II进行药代动力学和药效学分析”， 将于八月五日至六日在 美国国立卫生研究院 迪卡普里奥教授 由两名在使用ADAPT软件包方面有经验的国家癌症研究所科学家协助 (Dr. Steve Piscitelli和William Figg博士）。 超过20名NCI科学家 将出席这次为期两天的会议， 通过个人笔记本电脑访问ADAPT。 的 短期课程将侧重于使用ADAPT软件包， 建模、仿真、参数估计和实验设计 药代动力学和药效学。 个案研究将 介绍了ADAPT软件的应用， 解决各种建模、估计和实验设计 问题 案例研究涉及实际操作的计算机工作， 涵盖以下主题：药效学建模;贝叶斯 估计、极大似然和广义最小二乘 估计;多输出模型估计;抽样时间表 设计;生理模型模拟;具有时间延迟的模型;以及 用协变量建模

The second Advance Short Course, entitled "Modeling and Data Analysis in Pharmacokinetics and Pharmacodynamics Using ADAPT II", organized by Professor D'Argenio will be held on August 5-6, 1998 at the National Institutes of Health. Professor D'Argenio will be assisted by two NCI scientists experienced in using the ADAPT Package (Dr. Steve Piscitelli and Dr. William Figg). Over 20 NCI scientists are scheduled to attend this two-day meeting, with each participant accessing ADAPT through their individual notebook computers. The Short Course will focus on the use of the ADAPT software packages for modeling, simulation, parameter estimation, and design of experiments in pharmacokinetics and pharmacodynamics. Case studies will be presented illustrating the application of the ADAPT software for solving a variety of modeling, estimation, and experiment design problems. The Case Studies involves hands-on computer work and will cover the following topics: pharmacodynamic modeling; Bayesian estimation, maximum likelihood and generalized least squares estimation; estimation with multiple output models; sample schedule design; physiological model simulation; models with time delays; and modeling with covariates.