MAGNESIUM STATUS & REGULATION IN HEALTHY & SICK NEONATES

镁状况

• 批准号: 6205884
• 负责人: RONALD JT CORBETT
• 金额: $ 0.7万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-15 至 2000-08-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6205884
• 关键词: biomedical resource; child (0-11); female; hematology; human subject; infant mortality; low birth weight infant human; male; minerals; mother /infant health care; nuclear magnetic resonance spectroscopy; technology /technique

In this project, atomic absorption spectroscopy, nuclear magnetic resonance spectroscopy, and ion selective electrodes are being used to characterize the relative fractions of magnesium in the ionized, protein-bound, and ligand-complexed pools of the blood for normal and sick preterm and term neonates as well as maternal blood and cord blood. The broad goal is to use this new technology to obtain a more complete characterization of the distribution of Mg in blood, which in turn will provide a better understanding of magnesium regulation in pregnant women, preterm and sick infants, and lead to useful new clinical information which may alter the present management of these patients. Our preliminary results demonstrate the feasibility of quantifying the Mg pools in plasma, and the potential for large variations in the size of these pools to occur in both mother and infant during and following MgSO4 therapy. The data demonstrate that the intravenous infusion of MgSO4 does not simply add Mg2+ ions to a static solution of plasma. Although it has been recognized that the kidney is the main regulatory organ of Mg homeostasis, the preliminary results suggest that plasma is capable of partially buffering acute increases in ionized Mg, probably due to a combination of Mg buffering from both high and low affinity Mg binding ligands present in blood. There are indications that the extent of this buffering increases in response to hypermagnesemia over a period of hours. (Collaborative 4) REPORT PERIOD: (09/01/97-08/31/98)

在这个项目中，原子吸收光谱，核磁 共振光谱和离子选择性电极已用于 表征离子化镁的相对部分， 正常和 生病的早产，新生儿以及孕产妇和绳索 血。 广泛的目标是使用这项新技术获得更多 完全表征了血液中MG分布的表征 转弯将更好地理解镁的调节 孕妇，早产和生病的婴儿，并导致有用的新 可能会改变这些目前管理的临床信息 患者。 我们的初步结果证明了 量化等离子体中的MG池，并具有大的潜力 这些池大小的变化都发生在母亲和 在MGSO4治疗期间和之后的婴儿。 数据表明 MGSO4的静脉输注不简单地添加Mg2+离子 等离子体的静态溶液。 尽管已经认识到 肾脏是MG稳态的主要调节器官，即初步 结果表明血浆能够部分缓冲急性 电离毫克的增加，可能是由于MG缓冲的组合 来自血液中存在的高和低亲和力Mg结合配体。 有迹象表明这种缓冲的程度增加了 在几个小时内对高镁血症的反应。 （协作4） 报告期限：（09/01/97-08/31/98）