EPR TITRATION OF MUA TRANSPOSASE W/ MN(II)
EPR TITRATION OF MUA TRANSPOSASE W/ MN(II)
批准号:
6121161
负责人:
TANIA A BAKER
金额:
$0.39万
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-05-05 至 2000-04-30
中文摘要
EPR和共振拉曼的差异与Fe 3 +BLM聚
d(CG)与poly d(AT)相比。 Fe3+ BLM的多种构象
在缓冲液中以及药物与聚d(AT)结合时可见。 收窄
EPR吸收衍生物在结合到d(CG)或
DNA代表特定的相互作用,如共振所示
拉曼。 提出了一个模型,表明CG的药物识别
位点需要从氨基形成特定的氢键,
将BLM的嘧啶转化为碱基d(CG)。 写了一篇论文,
描述这项工作。
英文摘要
EPR and resonance Raman differences are seen with Fe3+BLM poly
d(CG) as compared to poly d(AT). Multiple conformers of the Fe3+ BLM
are seen in buffer and when the drug binds poly d(AT). Narrowing of
features of the EPR absorption derivative upon binding to d(CG) or to
DNA speak for specific interaction, as demonstrated by resonance
Raman. A model is presented suggesting that drug recognition of CG
sites entails the formation of a specific hydrogen bond from the amino
pyrimidine of BLM to a base d(CG). A paper has been written and
submitted describing this work.
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会议论文
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海外基金