课题基金 / 基金详情

AVONEX (IFN B1A) IN SUBJECTS AT HIGH RISK FOR DEVELOPMENT OF MULTIPLE SCLEROSIS

AVONEX (IFN B1A) IN SUBJECTS AT HIGH RISK FOR DEVELOPMENT OF MULTIPLE SCLEROSIS
AVONEX (IFN B1A) 用于多发性硬化症高风险受试者
批准号：
6121108
负责人：
STALEY armstrong BROD
金额：
$1.51万
依托单位：
UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6121108
关键词：
clinical research disease /disorder prevention /control drug administration routes human subject human therapy evaluation immunopathology chemotherapy immunotherapy interferon beta longitudinal human study multiple sclerosis nervous system disorder chemotherapy placebos

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相关文献

中文摘要
翻译
AVONEX是一种重组人干扰素β产品，是一种抗病毒蛋白，由成纤维细胞在病毒感染诱导后产生。这项随机、双盲、安慰剂对照研究将确定AVONEX是否有利于延迟首次和近期发生脱髓鞘事件的临床明确多发性硬化症的发作，以及多发性硬化症的高风险受试者。总共380名受试者将接受为期三年的静脉注射AVONEX或安慰剂治疗。
英文摘要
AVONEX, a recombinant human interferon-beta product, is an antiviral protein produced by fibroblasts after induction by viral infection. This randomized, double-blinded, placebo-controlled study will determine if AVONEX is beneficial in delaying the onset of clinically definite multiple sclerosis in subjects who have experienced a first and recent onset of a demyelinating event, and who are at high risk for multiple sclerosis. A total of 380 subjects will be treated with IM injections of AVONEX or placebo weekly for up to three years.
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会议论文
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