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AVONEX (IFN B1A) IN SUBJECTS AT HIGH RISK FOR DEVELOPMENT OF MULTIPLE SCLEROSIS

AVONEX (IFN B1A) IN SUBJECTS AT HIGH RISK FOR DEVELOPMENT OF MULTIPLE SCLEROSIS
AVONEX (IFN B1A) 用于多发性硬化症高风险受试者
批准号：
6309272
负责人：
STALEY armstrong BROD
金额：
$1.51万
依托单位：
UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-12-01 至 2001-02-28
来源：
https://reporter.nih.gov/project-details/6309272
关键词：
clinical research disease /disorder prevention /control drug administration routes human subject human therapy evaluation immunopathology chemotherapy immunotherapy interferon beta longitudinal human study multiple sclerosis nervous system disorder chemotherapy placebos

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相关文献

中文摘要
翻译
AVONEX是一种重组人干扰素-β产物，是一种病毒感染诱导后由成纤维细胞产生的抗病毒蛋白。 这项随机、双盲、安慰剂对照研究将确定AVONEX是否有利于延迟首次和近期发生脱髓鞘事件以及多发性硬化症高风险受试者的临床确诊多发性硬化症发作。 共计380例受试者将每周接受AVONEX或安慰剂IM注射治疗，持续3年。
英文摘要
AVONEX, a recombinant human interferon-beta product, is an antiviral protein produced by fibroblasts after induction by viral infection. This randomized, double-blinded, placebo-controlled study will determine if AVONEX is beneficial in delaying the onset of clinically definite multiple sclerosis in subjects who have experienced a first and recent onset of a demyelinating event, and who are at high risk for multiple sclerosis. A total of 380 subjects will be treated with IM injections of AVONEX or placebo weekly for up to three years.
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