CHEMICAL & NEURAL CONTROL OF PHARYNGEAL MUSCLE ACTIVITY

化学

• 批准号: 6265709
• 负责人: David P. White
• 金额: $ 4.66万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6265709
• 关键词: clinical research; hormone regulation /control mechanism; human subject; muscle function; neuroregulation; oxygen tension; respiratory airflow disorder; respiratory muscles; sleep; sleep apnea; testosterone; wakefulness

The purpose of this study is to determine the effect of testosterone on how the muscles of the upper airway function during wakefullness and sleep. These studies are aimed at understanding obstructive sleep apnea. This disorder is characterized by collapse of the pharyngeal airway recurrently during sleep leading to sleep disruption and repetitive falls in oxygen levels.

本研究的目的是确定睾酮对清醒和睡眠时上呼吸道肌肉功能的影响。这些研究旨在了解阻塞性睡眠呼吸暂停。这种疾病的特点是在睡眠中反复出现咽气道塌陷，导致睡眠中断和氧气水平反复下降。