MORPHOLOGY AND FUNCTION OF THE BASAL GANGLIA

这个计划项目的总体目标是继续我们的调查 的功能和发展的基底神经节使用各种 技术和准备由一个有凝聚力的科学家小组。 的 该建议的强度是基于一口井的延续 由一个紧密联系的主要团队建立的计划项目 调查人员（共同工作五年以上）， 代表形态学领域的不同背景， 电生理学、药理学和行为学，以及两个 主要研究者和共同研究者，其专长在于 分子和细胞生物学。 这些额外的、密切相关的项目 调查人员称赞现有的项目， 现有项目的科学前沿的维度， 也增加了另一个层面的尖端科学的电流 程序. 调查人员因一个共同的事业而团结在一起，即： 了解基底神经节的功能和发展下， 多学科、互补和高度互动的研究 程序. 两个核心（行政和中央设施）将 研究者合作共享，以便有效和高效地使用 行政人员，空间和设备。 我们计划调查：（1）的阐明和理解 大鼠纹状体靶细胞中发生的分子变化， 对阿片类药物挑战的反应;（2.）分子表征 和新纹状体中去神经支配的细胞后果;（3.）的 加强我们对DA在控制 纹状体神经元的活动;（4.）的细胞和分子 纹状体处理皮质输入的机制;（5.）的作用 基底神经节在刺激检测期间的运动控制中发挥作用， 分类、响应编程和选择（启动）， 响应产生（执行）;以及（6.）嫁接的程度 纹状体神经元具有以下特征性表型特征： 纹状体神经元以及它们是否类似于成熟或未成熟的纹状体神经元 细胞

The overall goal of this program project is to continue our investigation of the function and development of the basal ganglia using a variety of techniques and preparations by a cohesive group of scientists. The strength of this proposal is based on the continuation of a well established program project by a closely linked team of principal investigators (working together for more than five years), who possess diverse backgrounds representing the fields of morphology, electrophysiology, pharmacology, and behavior, AND the addition of two principal investigators and co-investigators whose expertise lie in molecular and cell biology. These additional, closely linked projects and investigators compliment the existing projects and also add another dimension of the cutting edge of science to the existing projects and also add another dimension of the cutting edge of science to the current program. The investigators are united by a common cause; namely, to understand the function and development of the basal ganglia under a multidisciplinary, complementary, and highly interactive research program. Two cores (administrative and central facilities) will be cooperatively shared by investigators for the effective and efficient use of administrative staff, space, and equipment. We plan to investigate: (1.) the elucidation and understanding of molecular changes that occur in target cells of the rat striatum in response to opiate challenge; (2.) the characterization of the molecular and cellular consequences of denervation in the neostriatum; (3.) the enhancement of our understanding of the roles of DA in the control of activities of striatal neurons; (4.) the cellular and molecular mechanisms by which the striatum processes cortical input; (5.) the role basal ganglia play in motor control during stimulus detection and classification, response programming, and selection (initiation) and response production (execution); and (6.) the extent to which grafted striatal neurons possess the characteristic phenotype features of striatal neurons and whether they resemble mature or immature striatal cells.