NONMELANOMA SKIN CANCER EPIDEMIOLOGY

项目三的目标是进一步了解 人体皮肤癌危险性与组织脂肪酸的相互关系 生物合成、表皮细胞增殖和紫外线辐射。 拟议的病例对照研究将包括1500名受试者，l）一个病例 最近诊断为皮肤癌的一组（375例基底细胞癌和375例 鳞状细胞受试者），和2）750名非癌症受试者的对照组。 这项研究可能有助于设计具有成本效益的皮肤癌 控制研究，并建议改善有关的风险， 皮肤癌研究人群将由婴儿和女性组成， 亚利桑那州南部的盎格鲁和西班牙裔白色居民， 皮肤癌风险因素的暴露范围。 先前确定的风险 还将评估因素，以控制混杂因素并测量 潜在的影响修改，包括紫外线曝光，现有的光化 角化病，色素沉着的特点，如痣，饮食 摄入量和皮下脂肪组织脂肪酸浓度。 暴露估计将基于结构化访谈， 对随机选择的基于人群的病例进行生化评估， 对照组。 将在初始阶段获得暴露估计值 面试，12个月后再次面试。

The objective of Project III is to further knowledge of the Interrelationship of the risk of human skin cancer and tissue fatty acid biosynthesis, epidermal cell proliferation, and ultraviolet radiation. The proposed case-control study will include 1500 subjects with l) a case group with a recent diagnosis of skin cancer (375 basal cell and 375 squamous cell subjects), and 2) a control group of 750 noncancer subject. The research may facilitate the design of cost effective skin cancer control studies and suggest improved guidelines related to the risk of skin cancer. The study population will be composed of bale and female, Anglo and Hispanic white residents of southern Arizona and provide broad exposure ranges for skin cancer risk factors. Previously identified risk factors will also be evaluated, to control for confounding and measure potential effect modification, including UV exposure, existing actinic keratosis, pigmentation characteristics such as number of nevi, dietary intake, and subcutaneous adipose tissue fatty acid concentrations. Exposure estimates will be based upon structured interview and biochemical assessment of randomly selected population-based cases and control groups. Exposure estimates will be obtained at the initial interview and again 12 months later.