A new model of T cell lymphoma induced by an Ets transcription factor

白血病致病基因的鉴定至关重要，因为一旦发现这些基因，就可以开发新的特异性药物。新药格列卫（Gleevec）就是最好的例证，它能抑制髓性白血病中的一种导致白血病的基因。这大大减少了高化疗治疗，但在大约80%的患者中引起了缓解。这项提议已经确定了一个新的白血病引起基因T细胞白血病。因此，现在可以研制出新的特异性药物来抑制它。

The identification of leukaemia-causing genes is crucial as once these are found new specific drugs can be developed. This is best exemplified by the new drug, Gleevec, that inhibits a leukaemia-causing gene in myeloid leukaemia. This has allowed a large reduction of high chemotherapy treatment but has induced remission in around 80% of patients. This proposal has identified a novel leukaemia-causing gene for T cell leukaemia. Therefore, new specific drugs can now be made to inhibit it.