A new model of T cell lymphoma induced by an Ets transcription factor

Ets转录因子诱导的T细胞淋巴瘤新模型

• 批准号: nhmrc : 559004
• 负责人: Dr David Izon
• 金额: $ 45.28万
• 依托单位: St. Vincent's Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/new-model-t-transcription-factor/77172
• 关键词: new; model; cell; lymphoma; induced

The identification of leukaemia-causing genes is crucial as once these are found new specific drugs can be developed. This is best exemplified by the new drug, Gleevec, that inhibits a leukaemia-causing gene in myeloid leukaemia. This has allowed a large reduction of high chemotherapy treatment but has induced remission in around 80% of patients. This proposal has identified a novel leukaemia-causing gene for T cell leukaemia. Therefore, new specific drugs can now be made to inhibit it.

识别导致白血病的基因至关重要，因为一旦发现这些基因，就可以开发新的特效药。新药格列卫就是最好的例证，它抑制了髓系白血病中的一种导致白血病的基因。这使得高度化疗的治疗大大减少，但大约80%的患者得到了缓解。这项建议发现了一个新的T细胞白血病的致病基因。因此，现在可以制造新的特定药物来抑制它。