The function of transcription factor SCL in T cell development.

转录因子SCL在T细胞发育中的功能。

• 批准号: nhmrc : 254587
• 负责人: Dr David Izon
• 金额: $ 33.66万
• 依托单位: St. Vincent's Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/function-transcription-factor-cell-development/76035
• 关键词: function; transcription; factor; SCL; cell

SCL is a gene which is abnormally expressed in a large percentage of human T cell leukaemias. Mouse models that increase SCL levels have demonstrated that T cell maturation is abnormally affected by SCL. Thus, providing a clue as to how T cell leukemias arise. By utilising recombinant DNA technology we are now able to control SCL levels in T cell maturation. We can either increase the level of SCL using pharmacological reagents or we can genetically remove SCL from maturing T cells. This double-edged approach will allow us to monitor the effects of SCL on maturing T cells with a precision that has never previously been achieved. Results from this approach will provide new insights into how T cell leukaemia develops and provide the foundation for new rational based treatments.

SCL是一种在很大比例的人类T细胞白血病中异常表达的基因。增加SCL水平的小鼠模型表明，T细胞成熟受到SCL的异常影响。因此，为T细胞白血病的产生提供了线索。通过利用重组DNA技术，我们现在能够控制T细胞成熟过程中的SCL水平。我们可以使用药理学试剂增加SCL的水平，或者我们可以从成熟的T细胞中通过基因去除SCL。这种双刃剑方法将使我们能够以前所未有的精度监测SCL对成熟T细胞的影响。这种方法的结果将为T细胞白血病的发展提供新的见解，并为新的合理治疗提供基础。