CORE--XENOGRAFT TRANSPLANTATION FACILITY

大型动物核心的目的将是协调和促进 所有研究者的子宫内基因治疗方案。 人事 在此核心的支持下，有着丰富的养羊经验 畜牧业和在特定方面的羊作为实验模型。 这包括在生存手术操作方面的丰富经验， 胎儿，植入长期留置胎儿导管 和血流探针。 在过去的一年里，我们还发展了专门知识， 在50天胎儿手术方法中。 核心服务将 提供的是： 1. 协调动物护理的各个方面。 2. 执行所有外科手术。 3. 移植动物的术后护理。 4. 监督产羔程序。 本补助金中提出的核心需求（每年12只羊）是 在现有人员和设施的能力范围内。 因此，优先次序将只涉及手术的安排， 细胞移植的时间

The purpose of the large animal core will be to coordinate and facilitate the in utero gene therapy protocols of all investigators. The personnel supported by this core have extensive experience in general sheep husbandry and in specific aspects of the sheep as an experimental model. This includes extensive experience in survival surgical manipulation of the fetus, with implantation of chronically indwelling fetal catheters and blood flow probes. In the past year we have also developed expertise in surgical approach to 50 day fetuses. The services that the core will provide are: 1. Coordination of all aspects of animal care. 2. Performance of all Surgical Procedures. 3. Post operative Care of transplanted animals. 4. Supervising lambing procedures. The demands on the core as proposed in this grant (12 sheep per year) are well within the capabilities of present personnel and facilities. Therefore, prioritization will involve only the scheduling of surgical time for cell transplantation.