Global Network for Women's and Children's Health

全球妇女儿童健康网络

• 批准号: 8400459
• 负责人: EDWARD A. LIECHTY
• 金额: $ 38.19万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-17 至 2013-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8400459
• 关键词: Acquired Immunodeficiency Syndrome; Acute; Adherence; Admission activity; Africa; African; Age-Months; Behavioral Sciences; Bioethics; Biological Preservation; Biometry; Catchment Area; Certification; Cessation of life; Child; Child health care; Childhood; Chlorine; Clinical Research; Communities; Computerized Medical Record; Control Groups; Data; Data Collection; Databases; Developing Countries; Diarrhea; Discipline of obstetrics; Education; Ensure; Epidemiology; Failure; Failure to Thrive; Family; Funding Agency; Growth; Head circumference; Health; Health Personnel; Health Promotion; Healthcare; Home environment; Home visitation; Hospital Referrals; Hospitals; House Call; Household; Incidence; Indiana; Individual; Infant; Infant Health; Infant Mortality; Institution; Institutional Review Boards; International; Intervention; Joints; Kenya; Lead; Length; Live Birth; Lung diseases; Medical Records; Morbidity - disease rate; Mothers; Multi-Institutional Clinical Trial; Neck; Neonatal; Neonatal Mortality; Pediatric Research; Population; Prevention; Prevention approach; Principal Investigator; Professional counselor; Protocols documentation; Public Health; Qualifying; Randomized; Recording of previous events; Rehydrations; Reporting; Research; Research Activity; Research Infrastructure; Research Personnel; Residual state; Resources; Rural; Rural Health; Rural Health Centers; Site; Social Marketing; Social Welfare; Sodium Hypochlorite; Stress; Supplementation; System; Testing; Time; Training; Universities; Vaccination; Village Health Workers; Vitamin A; Water; Weaning; Weight; Woman; Zinc; base; chlorination; clinical application; clinical care; data management; design; disorder prevention; drinking water; follow-up; group intervention; high risk infant; improved; indexing; international center; medical schools; member; mortality; nutrition; peer; postnatal; programs; protocol development; respiratory; wasting; water sampling; water treatment; working group

DESCRIPTION (provided by applicant): We propose to develop a Global Network for Women's and Children's Health Research site in Eldoret, Kenya. This East African site will be a joint partnership between Indiana University and Moi University School of Medicine, one of two medical schools in Kenya. The 17 year partnership of Moi University and Indiana University will bring unique strengths to the Global Network. These include an established administrative, scientific, and collegial relationship between the institutions, an extensive research infrastructure that includes an established network of rural health centers from which to draw subjects, a well functioning Kenyan Institutional Review Board with a OHRP Assurance number, and an established expanding coverage of subjects by an electronic medical record. The Senior Foreign Investigator is Dean of the Medical School, and has well established relationships with high level Ministry of Health personnel. A large number of other Moi University investigators with expertise in Obstetrics, Public Health, Nutrition, Epidemiology, and Behavioral Sciences are also eager to join the Global Network. US based expertise is also present in Obstetrics, Biostatistics, and Bioethics. We propose to the Network a cluster randomized protocol evaluating the efficacy of both Community Mobilization for the use of a Safe Water System (SWS) and for zinc supplementation in partially weaned infants less than 6 months of age. The SWS includes specially designed narrow neck water storage containers and point of use home chlorination using dilute sodium hypochlorite. Hypotheses to be tested are that 1.) Community Mobilization will result in sustained, consistent use of point of use water treatment 2.) This will lead to a decreased incidence of diarrhea in less than 6 month old infants. 3.) Zinc supplementation beginning at partial weaning will lead to a further decrease in the incidence of diarrhea in these infants. 4.) Growth will be improved and failure to thrive decreased in experimental groups. 5.) All cause mortality in >6 month old infants will be decreased in experimental groups. If efficacy is shown, these are highly sustainable interventions that will improve the health and well being of vulnerable infants.

描述(由申请人提供)：我们建议在肯尼亚埃尔多雷特建立一个全球妇女和儿童健康研究网络。这个东非网站将是印第安纳大学和莫伊大学医学院的联合合作伙伴关系，莫伊大学医学院是肯尼亚的两所医学院之一。莫伊大学和印第安纳大学长达17年的合作伙伴关系将为全球网络带来独特的优势。这些措施包括机构之间已建立的行政、科学和合作关系，广泛的研究基础设施，包括已建立的农村卫生中心网络，可从中提取受试者，运作良好的肯尼亚机构审查委员会，具有OHRP保证编号，以及已建立的通过电子医疗记录扩大受试者覆盖面的机制。高级外国调查员是医学院院长，与卫生部高层人员建立了良好的关系。MOI大学其他大量在产科、公共卫生、营养学、流行病学和行为科学方面具有专业知识的研究人员也渴望加入全球网络。美国的专业知识也存在于产科、生物统计学和生物伦理学。我们向该网络提出了一个集群随机方案，评估社区动员在使用安全水系统(SWS)和在不到6个月大的部分断奶婴儿中补充锌的有效性。SWS包括专门设计的窄颈储水容器和使用稀次氯酸钠的家用氯化处理设备。需要检验的假设是：1.)社区动员将导致持续、一致地使用使用点水处理2。)这将降低6个月以下婴儿的腹泻发病率。3.)在部分断奶时开始补充锌将进一步降低这些婴儿的腹泻发生率。4.)在试验组中，生长将得到改善，茁壮成长的失败将减少。5.)试验组6个月大婴儿的全因死亡率将会降低。如果显示出效果，这些是高度可持续的干预措施，将改善易受感染婴儿的健康和福祉。