EFFECT OF ARGININE SUPPLEMENT IN ADULTS WITH ESSENTIAL HYPERTENSION

补充精氨酸对患有原发性高血压的成人的影响

• 批准号: 6238956
• 负责人: Leticia Castillo
• 金额: $ 9.63万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 1998-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6238956
• 关键词: aldosterone; alternative medicine; aminoacid metabolism; arginine; arginine vasopressin; atrial natriuretic peptide; blood chemistry; blood pressure; catecholamines; cyclic GMP; dietary supplements; essential hypertension; human subject; nitric oxide; nutrient bioavailability; nutrition related tag; ornithine; renin; urea

L-arginine is a nutritionally dispensable amino acid, which is involved in many physiologic processes including nitric oxide (NO) synthesis. The L-arginine/NO pathway is a part of the normal process of cardiovascular autoregulation and it is probably deficient in patients with essential hypertension. L-arginine supplement prevent the induction of hypertension in rat-sensitive models and produce hypotension in healthy humans when given intravenously. The benefit of L-arginine supplementation has not clearly been demonstrated in humans with essential hypertension. This study will explore the in vivo adaptation mechanisms involved in arginine metabolism and homeostasis and in whole body nitric oxide production (measured as NO excretion) in such patients. We will also correlate metabolic data with a complete and exhaustive clinical evaluation. Ten patients will receive a controlled diet with a normal L-arginine intake (56.1 mg/Kg/day) and then an arginine-supplemented (561 mg/Kg/day) isonitrogenous diet. Clinical outcome measures include daily blood pressure, as well as catecholamines, hANP, AVP, aldosterone, cGMP level and renin activity on day one and day seven of each diet period. At the end of each diet period, an 8h stable-isotopic labelled tracer study will be performed to evaluate the arginine, ornithine and urea fluxes as well s the NO production via measurement of nitrite/nitrate. This project will shed new light on the potential benefit of arginine supplement in diseases involving the L-arginine/NO pathway, such as essential hypertension. It will also define more completely the metabolic basis underlying body arginine homeostasis in human adults.

L-精氨酸是一种营养上不可或缺的氨基酸， 参与许多生理过程，包括硝酸 氧化物（NO）合成。 L-精氨酸/NO途径是 心血管自动调节的正常过程， 它可能是缺乏病人的基本 高血压 补充L-精氨酸可防止诱导 高血压在大鼠敏感模型和生产 健康人静脉注射时的低血压。 补充L-精氨酸的益处还不清楚 在原发性高血压患者中得到证实。 本研究将探讨在体内的适应机制 参与精氨酸代谢和体内平衡， 全身一氧化氮产生（以NO 在这些患者中， 我们还将关联 代谢数据与完整和详尽的临床 评价 10名患者将接受控制饮食 正常L-精氨酸摄入量（56.1 mg/Kg/天），然后 一个补充了精氨酸（561 mg/Kg/天）的等氮 饮食. 临床结局指标包括每日血液 压力，以及儿茶酚胺、hANP、AVP， 第1天醛固酮、cGMP水平和肾素活性， 每个饮食周期的第七天。 每次节食结束时 期间，将进行8小时稳定同位素标记示踪剂研究， 进行评价精氨酸、鸟氨酸和尿素 通量以及通过测量NO的产生 亚硝酸盐/硝酸盐。 这个项目将为我们提供新的视角， 精氨酸补充剂在疾病中的潜在益处 涉及L-精氨酸/NO途径，如必需的 高血压 它还将更完整地定义 精氨酸稳态的代谢基础 人类成年人