CORE--PROGRAM SYNTHETIC CORE

核心--程序合成核心

• 批准号: 6240527
• 负责人: TOMAS HUDLICKY
• 金额: $ 11.52万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 1998-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6240527
• 关键词: alcohols; anesthetics; biomedical facility; bromine; chemical synthesis; chlorine; ethers; halocarbon compound; hydrogen; pharmacokinetics

The series of halogenated n-alkanes contains compounds that do and do not produce anesthesia. We propose to synthesize a number of compounds that lie near the border of the anesthetic and nonanesthetic domains. The synthesis of the following compounds will be investigated, either by existing methods or by methods we will develop: (1) polyfluorinated n- alkanes containing hydrogen and/or chlorine atoms, or bromine atoms at one or both of the terminal carbons; (2) dibromoperfluorocyclobutane and cyclopentane; (3) polyfluorinated methyl ethyl ethers containing hydrogen and/or chlorine atoms, or bromine atoms on one or both of the terminal carbons; (4) polyfluorinated alcohols. Over the period of the program project we will prepare 24 compounds according to the directives of the Core and supply these of all the investigators. We will also address resynthesis of samples and provide the flexibility to respond to any shifts in focus as dictated by the Core. Our participation in this Program Project will add another dimension to the project. We will contribute the viewpoint of the fluorine chemist. This might be particularly helpful in the discussions of the group concerning the implications of the physical properties of these compounds and the factors that distinguish anesthetic from nonanesthetic compounds. The significance of our contribution apart from providing the needed compounds, some of which we have made previously, lie in the improvements we will contribute to the known methods of synthesis and to the scale-up technology required to produce the compounds on a medium scale.

卤代正构烷烃系列包含含有和不含有的化合物 制造麻醉剂。我们建议合成一些化合物，这些化合物 位于麻醉和非麻醉领域的边界附近。这个 以下化合物的合成将通过以下方式进行研究 现有方法或通过我们将开发的方法：(1)多氟化n- 含有氢和/或氯原子或溴原子的烷烃 端碳中的一种或两种；(2)二溴环氟环丁烷和 环戊烷；(3)含氢的多氟甲基乙醚 和/或氯原子，或溴原子在末端的一个或两个上 碳；(4)多氟醇。在该计划期间 项目我们将按照指导方针制备24种化合物。 核心，并提供这些所有的调查人员。我们还将解决 样品的重新合成，并提供灵活性，以响应任何 核心所决定的焦点转移。 我们参与此计划项目将增加另一个维度 这个项目。我们将发表氟化学家的观点。 这可能对工作组的讨论特别有帮助。 关于这些化合物的物理性质的含义 以及区分麻醉剂和非麻醉剂化合物的因素。 我们的贡献的意义除了提供所需的 化合物，其中一些我们以前已经做过了，在于改进 我们将为已知的合成方法和放大做出贡献 生产中等规模的化合物所需的技术。