UHC/CWRU ADRC COMPETITIVE RENEWAL

在其存在的前四年，我们的NIA ADRC已经发展成为一个 基础广泛的研究企业，具有重大的，地方和国家的影响。 我们的提案包括四个必需的核心：行政，临床， 神经病理学，研究培训和信息传输（RTIT）。 在 除了我们现有的患者登记和数据管理分析 组件，我们的临床核心已经成长与最近的竞争力 资助增加精神病理学评估部分和NIA 卫星ADRC。 此外，我们还增加了NIA资助的护理人员核心 为临床和社会研究提供数据， 我们专利的保护者。 我们的RTIT核心已经扩展， 有竞争力的资金和大量的参与，从当地和 全国老年痴呆症协会 在这项新的应用中，六项研究 项目包括在内。 两项基本的生物学研究涉及新的， 最近在我们中心招聘的高级教师：G。兰德雷思 淀粉样蛋白和胶质细胞之间的关系;和K.转基因动物 阿尔茨海默病（AD）的模型。 另外两个新项目涉及C。 Gilmore，研究AD和D. Ripich评估少数民族和非少数民族照顾者的沟通; M.帕特森正在努力描述行为症状 AD和K。Smyth正在努力使用 与我们的两个新核心有着紧密联系的护理人员。 我们强壮的飞行员 节目继续。 超过50名教师和其他高级调查员 参与我们在大学的AD研究工作，许多人 通过试点项目进入市场。 更新飞行员作为 范围与我们的研究项目一样广泛，从基本的 生物学（S. Younkin，淀粉样蛋白加工）到临床（J. Fagan，视觉 注意和K。史密斯，洞察力和否认疾病）。我们提出的 扩展国家信息评估与发展研究中心将使我们能够继续发挥领导作用 在迅速推进的国家和国际努力中， 反倾销和改善其受害者的生活质量。

In its first four years of existence, our NIA ADRC has developed as a broad based research enterprise with major, local and national impact. Our proposal includes the four required cores: Administrative, Clinical, Neuropathology, Research Training and Information Transfer (RTIT). In addition to our existing Patient Registry and Data Management Analysis Components, our clinical core has grown with the recent competitively funded additions of a Psychopathology Assessment Component and NIA Satellite ADRC. Moreover, we have added an NIA funded Caregiver Core that provides data for clinical and social research on characteristics of the caregivers of our patents. Our RTIT core has expanded with competitive funding and considerable involvement from the local and national Alzheimer's Association. In this new application, six research projects are included. Two basic biological studies involve new, recently recruited senior faculty members in our center: G. Landreth the relationship between amyloid and glia; and K. Herrup on transgenic animal models of Alzheimer's disease (AD). Two other new projects involve C. Gilmore, studying the cognitive basis of visual disturbances in AD and D. Ripich evaluating communication in minority and nonminority caregivers; M. Patterson is leading efforts to characterize the behavioral symptoms of AD and K. Smyth is leading efforts in the use of services of caregivers with strong linkages to our two new cores. Our strong pilot program continues. Of over 50 faculty and other senior investigators involved with our AD research efforts at the University, many were introduced to the field through the pilot program. The renewal pilots as similarly broad in scope as our research projects ranging from basic biology (S. Younkin, amyloid processing) to clinical (J. Fagan, visual attention and K. Smyth, insight and denial of illness). Our proposed expansion of the NIA ADRC will allow us to continue our leadership role in the rapidly advancing national and international efforts to understand AD and improve the quality of lives of its victims.