UHC/CWRU ADRC COMPETITIVE RENEWAL

在其存在的头四年里，我们的NIA ADRC已经发展成为 基础广泛，具有重大、地方和全国影响的研究企业。 我们的建议包括四个必需的核心：行政、临床、 神经病理学、研究训练和信息传输(RTIT)。在……里面 添加到我们现有的患者注册表和数据管理分析 组件，我们的临床核心随着最近具有竞争力的 资助增加一个精神病理学评估部分和国家行为监管局 卫星ADRC。此外，我们还增加了NIA资助的Caregiver Core 这为临床和社会研究提供了数据 我们专利的照顾者。我们的RTIT核心已扩展为 有竞争力的资金和当地和地方政府的大量参与 全国阿尔茨海默氏症协会。在这一新的应用中，有六项研究 项目也包括在内。两项基本的生物学研究涉及新的， 最近在我们中心招聘的高级教员：G.Landreth the 淀粉样蛋白与胶质细胞的关系；转基因动物上的K.Herrup 阿尔茨海默病(AD)模型。另外两个新项目涉及C. Gilmore，研究了AD和D的视觉障碍的认知基础。 Ripich评估少数族裔和非少数族裔照顾者之间的沟通； M.Patterson正在领导对行为症状进行表征的努力 AD和K.Smyth正在领导使用以下服务的努力 与我们的两个新核心有密切联系的护理者。我们强大的飞行员 节目继续。50多名教职员工和其他高级调查人员 参与了我们在大学的AD研究工作，许多人 通过试点计划引入现场。续航试点AS 与我们的研究项目一样，范围也同样广泛，从基础 生物学(S.Young kin，淀粉样蛋白处理)到临床(J.Fagan，视觉 关注和K.Smyth、洞察力和否认疾病)。我们的建议 NIA ADRC的扩大将使我们能够继续发挥领导作用 在迅速推进的国家和国际努力中 广告和提高受害者的生活质量。

In its first four years of existence, our NIA ADRC has developed as a broad based research enterprise with major, local and national impact. Our proposal includes the four required cores: Administrative, Clinical, Neuropathology, Research Training and Information Transfer (RTIT). In addition to our existing Patient Registry and Data Management Analysis Components, our clinical core has grown with the recent competitively funded additions of a Psychopathology Assessment Component and NIA Satellite ADRC. Moreover, we have added an NIA funded Caregiver Core that provides data for clinical and social research on characteristics of the caregivers of our patents. Our RTIT core has expanded with competitive funding and considerable involvement from the local and national Alzheimer's Association. In this new application, six research projects are included. Two basic biological studies involve new, recently recruited senior faculty members in our center: G. Landreth the relationship between amyloid and glia; and K. Herrup on transgenic animal models of Alzheimer's disease (AD). Two other new projects involve C. Gilmore, studying the cognitive basis of visual disturbances in AD and D. Ripich evaluating communication in minority and nonminority caregivers; M. Patterson is leading efforts to characterize the behavioral symptoms of AD and K. Smyth is leading efforts in the use of services of caregivers with strong linkages to our two new cores. Our strong pilot program continues. Of over 50 faculty and other senior investigators involved with our AD research efforts at the University, many were introduced to the field through the pilot program. The renewal pilots as similarly broad in scope as our research projects ranging from basic biology (S. Younkin, amyloid processing) to clinical (J. Fagan, visual attention and K. Smyth, insight and denial of illness). Our proposed expansion of the NIA ADRC will allow us to continue our leadership role in the rapidly advancing national and international efforts to understand AD and improve the quality of lives of its victims.