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AM/500 NMR CONSOLE UPGRADE

AM/500 NMR 控制台升级

基本信息

批准号：
2040633
负责人：
Kevin J. Lumb
金额：
$ 30.06万
依托单位：
COLORADO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-06-01 至 1999-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2040633
关键词：
biomedical equipment purchase nuclear magnetic resonance spectroscopy

项目摘要

A console upgrade for a Bruker AM-500 nuclear magnetic resonance (NMR) spectrometer is proposed. This upgraded instrument will be available to the eleven major users on a twenty-four hour basis for their NIH-funded studies. The upgraded 500 MHZ NMR will continue to be operated as a departmental service to the major users and the research community at Colorado State University. The new console will offer to the major users increased sensitivity and more convenient access to the direct detection of NMR nuclei as the result of the new dual-broadband probe. The new console will have reduced noise, increased stability, improved dynamic range, dramatic improvements to RF control in both channels, precise temperature control, flexible observe and de-couple capabilities, z-axis gradient enhanced spectroscopy, selective excitation, shaped pulses and multiple simultaneous (multiplexed) region selective pulses. Both new, state-of-the-art techniques and well-proven (but dramatically improved) techniques will be available for these NIH-supported studies, including various one and multi-dimensional gradient-enhanced methods (e.g., GOESY, NOESY, HSQC, HMBC, MQFCOSY and various hyphenated versions of these experiments), broadband channel de-coupling, bio-molecular NMR in H2O, NMR studies in other protio- solvents, rotating frame experiments (e.g., ROESY, TOCSY. HoHAHA), and selective pulse experiments.

布鲁克AM-500核磁共振(核磁共振)的控制台升级提出了分光计的概念。这款升级的仪器将可用于 NIH资助的11个主要用户的24小时服务学习。升级后的500兆赫核磁共振将继续作为为主要用户和研究团体提供的部门服务，网址为科罗拉多州立大学。新的游戏机将为主要用户提供更高的灵敏度和更方便的直接检测作为新的双宽带探测器的结果的核磁共振核。新的控制台将降低噪音、提高稳定性、改进动态范围，两个通道中射频控制的显著改进，温度控制精确，观察灵活，解耦灵活功能，z轴梯度增强光谱学，选择性激励、整形脉冲和多个同时(多路)区域选择性脉冲。既有新的、最先进的技术，也有经过充分验证的 (但大大改进)的技术将可用于这些 NIH支持的研究，包括各种一维和多维的研究梯度增强方法(例如，GOESY、NOESY、HSQC、HMBC、MQFCOSY和这些实验的各种连字符版本)、宽带通道去偶联，水中的生物分子核磁共振，其他蛋白质的核磁共振研究。溶剂，旋转框架实验(例如，ROESY，TOCSY。呼哈哈)，以及选择性脉冲实验。