METAL MEDIATED SCHIFF BASES FOR MEDICINAL AGENT SYNTHESIS

我们的研究旨在开发低成本和高效率的非对称 用于药物合成的实际用途的催化剂，例如，合成 生物活性天然产物和伦理药物中间体 件. 随后，我们将这些不对称催化剂应用于 对药物合成很重要的有机转化。 这 项目将明确解决发展的重要问题， 手性药物 我们的研究的其他组成部分包括（1） 基于过渡金属络合物的生物活性剂的开发， g.g.，钛、铂和锡络合物。 这些因素的相互作用 将研究与生物分子的复合物， 了解抗肿瘤药物的结构和结合性质， 生物系统;（2）开发新的配体和宿主分子， 选择性地结合重金属和有毒（客体）分子对健康有益 相关的环境评估和补救。

Our research is aimed to develop low-cost and highly efficient asymmetric catalysts for practical uses in pharmaceutical syntheses, e.g., syntheses of intermediates of biologically active natural products and ethical drug components. Subsequently, we will apply these asymmetric catalysts to organic transformations important to the pharmaceutical syntheses. This project will clearly address important issues towards development of chiral medicines. Other components of our research include (1) development of bioactive agents based on transition metal complexes, g.g., titanium, platinum and tin complexes. The interaction of these complexes with the biomolecules will be investigated to gain understanding of structural and binding nature of anti-tumor drugs in biosystem; (2) development of new ligands and host molecules which will selectively bind heavy metals and toxic (guest) molecules for health related environmental evaluation and remediation.