METAL MEDIATED SCHIFF BASES FOR MEDICINAL AGENT SYNTHESIS

用于药物合成的金属介导席夫碱

• 批准号: 6240340
• 负责人: XIU R BU
• 金额: $ 11.79万
• 依托单位: CLARK ATLANTA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-02-01 至 1998-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6240340
• 关键词: Schiff bases; antineoplastics; biological products; catalyst; chemical binding; drug design /synthesis /production; metal complex; platinum; stereoisomer; tin; titanium

Our research is aimed to develop low-cost and highly efficient asymmetric catalysts for practical uses in pharmaceutical syntheses, e.g., syntheses of intermediates of biologically active natural products and ethical drug components. Subsequently, we will apply these asymmetric catalysts to organic transformations important to the pharmaceutical syntheses. This project will clearly address important issues towards development of chiral medicines. Other components of our research include (1) development of bioactive agents based on transition metal complexes, g.g., titanium, platinum and tin complexes. The interaction of these complexes with the biomolecules will be investigated to gain understanding of structural and binding nature of anti-tumor drugs in biosystem; (2) development of new ligands and host molecules which will selectively bind heavy metals and toxic (guest) molecules for health related environmental evaluation and remediation.

我们的研究目标是开发低成本、高效率的不对称材料