SCOR IN PEDIATRIC CARDIOVASCULAR DISEASE

小儿心血管疾病中的 SCOR

• 批准号: 2029031
• 负责人: Bradley Barth Keller
• 金额: $ 131.07万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-01-01 至 1998-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2029031
• 关键词: biomechanics; congenital cardiovascular disorder; pediatrics

This SCOR proposal for a Pediatric Cardiovascular Disease Center is a series of fundamental studies aimed at understanding the biomechanical aspects of cardiac development to normal cardiovascular development and human congenital cardiac defects. The heart is the first functioning organ in the embryo. The embryonic heart is transformed by genetic and epigenetic factors from a tube to a four chambered heart. Errors in this development process produce a wide spectrum of congenital heart defects. Rapid advances in molecular and cellular biology are identifying genetic pathways integral to development. Less is known, however, about the mechanical forces that drive morphogenesis and growth from uncoiling of the DNA strand prior to transcription to the cardiac pumping cycle. Thus, the biomechanical forces at all levels of the developing heart have a central role in formation of the heart and circulation. The long term aid of this SCOR Project is to define supports sophisticated analytic techniques in three cores: Bioengineering, Cardiovascular Physiology and Morphometry to understand mechanisms that interrelate function and form during normal and abnormal cardiovascular morphogenesis. Four projects apply the multidisciplinary expertise available in each core to study: 1. The heart rate and blood flow velocity variability in the human from 10 to 18 weeks gestation. 2. Ventricular/vascular coupling during cardiovascular development. 3. Biomechanical modeling of growth and morphogenesis of the embryonic hear. 4. Atrial/ventricular coupling during cardiovascular development. These studies are fundamental to understanding the biomechanical environment of the developing heart and circulation and provide important information on pathogenetic mechanisms of congenital and acquired cardiovascular disease in humans.

这份关于建立儿科心血管疾病中心的SCOR提案是 旨在了解生物力学的一系列基础研究 心脏发育的各个方面与正常心血管发育和 人类先天性心脏缺陷。心脏是第一个起作用的 胚胎中的器官。胚胎心脏是由基因和 表观遗传因素，从一根管子到一个四腔心脏。此中的错误 发育过程中会产生各种各样的先天性心脏缺陷。 分子和细胞生物学的快速发展正在识别基因 发展不可或缺的途径。然而，人们对这一事件知之甚少 推动形态发生和生长的机械力 转录前的DNA链进入心脏泵动周期。 因此，发育中的心脏各个水平上的生物机械力 在心脏和血液循环的形成中起核心作用。从长远来看 此SCOR项目的帮助是定义支持复杂的分析 三大核心技术：生物工程、心血管生理学和 形态计量学，以了解功能和形式相互关联的机制 在正常和异常的心血管形态发生过程中。四个项目 应用每个核心中提供的多学科专业知识来研究： 1.人体心率和血流速度变异性 妊娠10至18周。 2.心血管发育过程中的心室/血管偶联。 3.胚胎生长和形态发生的生物力学模型 听见。 4.心血管发育过程中的房室耦合。 这些研究是理解生物力学的基础。 为发育中的心脏和血液循环提供重要的环境 先天性和获得性骨质疏松症的发病机制 人类的心血管疾病。