SCOR IN PEDIATRIC CARDIOVASCULAR DISEASE

SCOR关于儿科心血管疾病中心的建议是一个 一系列旨在理解生物力学的基础研究 从心脏发育到正常心血管发育， 人类先天性心脏缺陷 心脏是第一个运作的器官 胚胎中的器官 胚胎心脏是由基因和 从试管到四腔心脏的表观遗传因素 错误在此 发展过程中产生了广泛的先天性心脏缺陷。 分子和细胞生物学的快速发展正在确定遗传 是发展不可或缺的途径。 然而，对这一点知之甚少。 机械力驱动形态发生和生长， 在转录到心脏泵血周期之前的DNA链。 因此，发育中的心脏的各个层面的生物力学力 在心脏和循环的形成中起核心作用。 长期 该SCOR项目的一个帮助是定义支持复杂的分析 三大核心技术：生物工程、心血管生理学和 形态测量学，以了解功能和形式相互关联的机制 在正常和异常的心血管形态发生期间。 四个项目 运用每个核心的多学科专门知识研究： 1.心率和血流速度变异性在人类从 怀孕10到18周。 2.心血管发育过程中的心室/血管偶联。 3.胚胎生长和形态发生的生物力学模拟 听 4.心血管发育过程中的心房/心室耦合。 这些研究是理解生物力学的基础 环境的发展心脏和循环，并提供重要的 关于先天性和后天性 人类心血管疾病。

This SCOR proposal for a Pediatric Cardiovascular Disease Center is a series of fundamental studies aimed at understanding the biomechanical aspects of cardiac development to normal cardiovascular development and human congenital cardiac defects. The heart is the first functioning organ in the embryo. The embryonic heart is transformed by genetic and epigenetic factors from a tube to a four chambered heart. Errors in this development process produce a wide spectrum of congenital heart defects. Rapid advances in molecular and cellular biology are identifying genetic pathways integral to development. Less is known, however, about the mechanical forces that drive morphogenesis and growth from uncoiling of the DNA strand prior to transcription to the cardiac pumping cycle. Thus, the biomechanical forces at all levels of the developing heart have a central role in formation of the heart and circulation. The long term aid of this SCOR Project is to define supports sophisticated analytic techniques in three cores: Bioengineering, Cardiovascular Physiology and Morphometry to understand mechanisms that interrelate function and form during normal and abnormal cardiovascular morphogenesis. Four projects apply the multidisciplinary expertise available in each core to study: 1. The heart rate and blood flow velocity variability in the human from 10 to 18 weeks gestation. 2. Ventricular/vascular coupling during cardiovascular development. 3. Biomechanical modeling of growth and morphogenesis of the embryonic hear. 4. Atrial/ventricular coupling during cardiovascular development. These studies are fundamental to understanding the biomechanical environment of the developing heart and circulation and provide important information on pathogenetic mechanisms of congenital and acquired cardiovascular disease in humans.