IMMUNE & HEMATOPOIETIC PARAMETERS IN CHIMPANZEES AS THEY PROGRESS TOWARDS AIDS

免疫

• 批准号: 6247349
• 负责人: F VILLINGER
• 金额: $ 7.55万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-05-01 至 1998-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6247349
• 关键词: AIDS; Mammalia; Primates; animal tissue; blood; communicable diseases; immunology; lymphatic system; virus

A cohort of chimpanzees was infected with various HIV-1 isolates in the years 1984-86. After a 10 year asymptomatic period, one ape developed anemia, CD4+ T cell loss and opportunistic infections similar to human AIDS. A second animal transfused with blood from the "sick" chimpanzee was shown to suffer a dramatic CD4+ T cell loss post transfusion. A number of additional animals infected with LAV in this cohort appear to experience progressive CD4+ T cell loss as well. Since sequential blood samples had been collected and stored during most of the "clinically asymptomatic" period, our goal was to attempt to delineate immune parameters that accompany/predict the clinical demise in these animals. Further, we attempted to define the hematological abnormalities induced by this selected variant of HIV-1 that leads to nonregenerative anemia and finally death. Results obtained on the first 2 animals have been presented at the 14th Symposium on Nonhuman Primate Models for AIDS a nd are being published as a manuscript in the Journal of Medical Primatology.

一组黑猩猩感染了各种HIV-1分离株 在1984-86年间。 在10年的无症状期后，一只猿 出现贫血、CD 4 + T细胞丢失和机会性感染 类似于人类艾滋病。 第二只动物输了来自 研究表明，一只“生病”的黑猩猩在接受治疗后， 输血 在这一过程中， 队列似乎也经历了进行性CD 4 + T细胞损失。 由于连续的血液样本已经收集和储存， 在“临床无症状”的大部分时间里，我们的目标是尝试 描述伴随/预测临床疾病的免疫参数， 这些动物的死亡。 此外，我们试图定义 由这种选定的HIV-1变异体引起的血液学异常 导致非再生性贫血最终死亡 结果 在第14届会议上， 艾滋病非人灵长类动物模型研讨会， 发表在《医学灵长类学杂志》上