CLONING, ANALYSIS & EXPRESS OF PRIMATE CYTOKINES, CHEMOKINES, IMMUNE RECEPTORS

最近的治疗尝试包括各种细胞因子， 造血生长因子，或用于调节的特定配体 免疫反应和造血功能用于治疗各种疾病 临床条件或作为免疫方案的佐剂。一个 大量这样的应用被研究使用不同的 非人灵长类动物模型，尽管大多数人为因素出现 在非人类灵长类动物中具有生物活性，数据显示注射 人类重组细胞因子通常不允许重复或 由于快速发展的免疫反应而进行的长期治疗 这些“外来”分子，导致失活和 清除这些细胞因子。此外，猪瘟的免疫应答 灵长类细胞对某些人类细胞因子的刺激 发现明显低于等效细胞的响应 人类起源。这些研究具有快速翻译的潜力 用于治疗人类疾病的治疗应用。

Recent therapeutic attempts include a variety of cytokines, hematopoietic growth factors, or specific ligands for the modulation of immune responses and hematopoiesis for the treatment of various clinical conditions or as adjuvant to immunization protocols. A significant number of such applications are studied using various nonhuman primate models, yet while most human factors appear biologically active in nonhuman primates, data shows that injection of human recombinant cytokines most often does not allow repeated or long-term treatment due to rapid development of an immune response towards these "foreign" molecules, resulting in inactivation and clearance of these cytokines. Furthermore the immune response of primate cells to the stimulation by certain human cytokines has been found to be markedly lower than the response of equivalent cells from human origins. These studies bear the potential to rapidly translate into therapeutic applications for the treatment of human diseases.