课题基金 / 基金详情

CLONING, ANALYSIS & EXPRESS OF PRIMATE CYTOKINES, CHEMOKINES, IMMUNE RECEPTORS

CLONING, ANALYSIS & EXPRESS OF PRIMATE CYTOKINES, CHEMOKINES, IMMUNE RECEPTORS
克隆、分析
批准号:
6277476
负责人:
F VILLINGER
金额:
$5.38万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-05-01 至 1999-04-30

项目摘要

项目成果

F VILLINGER的其他基金

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相关文献

中文摘要
翻译
最近的治疗尝试包括多种细胞因子,
英文摘要
Recent therapeutic attempts include a variety of cytokines, hematopoietic growth factors, or specific ligands for the modulation of immune responses and hematopoiesis for the treatment of various clinical conditions or as adjuvant to immunization protocols. A significant number of such applications are studied using various nonhuman primate models, yet while most human factors appear biologically active in nonhuman primates, data shows that injection of human recombinant cytokines most often does not allow repeated or long-term treatment due to rapid development of an immune response towards these "foreign" molecules, resulting in inactivation and clearance of these cytokines. Furthermore the immune response of primate cells to the stimulation by certain human cytokines has been found to be markedly lower than the response of equivalent cells from human origins. These studies bear the potential to rapidly translate into therapeutic applications for the treatment of human diseases.
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CLONING, ANALYSIS NON HUMAN PRIMATE CYTOKINES, IMMUNE RECEPTORS
  • 批准号:
    6593914
  • 项目类别:
  • 资助金额:
    $20.91万
  • 财政年份:
    2002
  • 负责人:
    F VILLINGER
  • 依托单位:
CLONING, ANALYSIS NON HUMAN PRIMATE CYTOKINES, IMMUNE RECEPTORS
  • 批准号:
    6116257
  • 项目类别:
  • 资助金额:
    $8.47万
  • 财政年份:
    1999
  • 负责人:
    F VILLINGER
  • 依托单位:
NONHUMAN PRIMATE CYTOKINES, CHEMOKINES & SECONDARY SIGNAL MOLECULES
  • 批准号:
    6247350
  • 项目类别:
  • 资助金额:
    $7.55万
  • 财政年份:
    1997
  • 负责人:
    F VILLINGER
  • 依托单位:
IMMUNE & HEMATOPOIETIC PARAMETERS IN CHIMPANZEES AS THEY PROGRESS TOWARDS AIDS
  • 批准号:
    6247349
  • 项目类别:
  • 资助金额:
    $7.55万
  • 财政年份:
    1997
  • 负责人:
    F VILLINGER
  • 依托单位:
海外基金