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Genes of past, present and future: does legacy pollution contribute to antibiotic resistance in industrialised estuaries?

过去、现在和未来的基因：遗留污染是否会导致工业化河口的抗生素耐药性？

基本信息

批准号：
NE/N019474/1
负责人：
Fiona Henriquez
金额：
$ 23.02万
依托单位：
University of the West of Scotland
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2016
资助国家：
英国
起止时间：
2016 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=NE%2FN019474%2F1
关键词：
Genes past present future does

项目摘要

Development of antibiotic resistant (AR) bacteria diminishes the efficacy of antibiotics to the point that difficult-to-treat pathogens are encountered in water, beaches and seafood. Although the inappropriate use of antibiotics in medicine and agriculture contributes to the problem, there is evidence that industrial pollution (e.g., organics and heavy-metal pollutants) have a strong role in AR development.Can residual pollution in the environment from past industrial pollution continue to threaten present and future public/environmental health? Many chemicals do degrade in nature; however, certain signatures, e.g., persistent polycyclic aromatic hydrocarbons (PAH) and heavy metals can remain in sediments providing continual stress to resident microorganisms.Bacteria have the ability to acquire and disseminate mechanisms to deal with chemical stress; some of these mechanisms are either analogous or closely-linked (genetically) to genes to that provide antibiotic resistance. Therefore, the presence of metals (for example) can cause bacteria to harbour and spread these stress-response genes.In this project, we will obtain sediment cores in former/current industrial areas along the Clyde estuary near Glasgow. We will determine chemical signatures in sediment layers and use radiometric (lead and caesium) assessment to determine "pollution age". Simultaneously, we will characterise the resident bacterial populations (via 16S-rRNA analysis) and types of resistance genes (metal and antibiotic) that they harbour to determine whether risk exist in zones of pollution.Having the ability to compare different pollution conditions among stratified layers in the sediment and among different locations along the estuary; it will allow us to determine contributing factors towards resistance traits in microbial communities. This research will better inform us the risks associated with industrial pollution, and it can influence pollution-control and remediation strategies.

抗生素耐药性（AR）细菌的发展降低了抗生素的功效，以至于在水，海滩和海鲜中遇到难以治疗的病原体。尽管抗生素在医学和农业中的不适当使用导致了这一问题，但有证据表明，工业污染（例如，有机物和重金属污染物）在AR发展中起着重要作用。过去工业污染的环境残留污染是否会继续威胁现在和未来的公众/环境健康？许多化学品在自然界中确实会降解;然而，某些特征，例如，持久性多环芳烃（PAH）和重金属可残留在沉积物中，为常驻微生物提供持续的压力。细菌有能力获得和传播应对化学压力的机制;其中一些机制与提供抗生素抗性的基因相似或密切相关（遗传）。因此，金属的存在（例如）可以导致细菌窝藏和传播这些应激反应基因。在本项目中，我们将获得沿着格拉斯哥附近克莱德河口的前/当前工业区的沉积物岩心。我们将确定沉积层中的化学特征，并使用放射性（铅和铯）评估来确定“污染年龄”。与此同时，我们将对常驻细菌种群进行分类，（通过16 S-rRNA分析）和抗性基因类型（金属和抗生素），以确定污染区是否存在风险，能够比较沉积物分层之间和河口沿着不同地点之间的不同污染状况;它将使我们能够确定微生物群落中抗性性状的影响因素。这项研究将更好地告知我们与工业污染相关的风险，它可以影响污染控制和补救策略。

项目成果

期刊论文数量（8）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Antimicrobial Resistance as a Global Health Threat: The Need to Learn Lessons from the COVID-19 Pandemic.

DOI：
10.1111/1758-5899.13049
发表时间：
2022-05
期刊：
GLOBAL POLICY
影响因子：
1.9
作者：
Cameron, Anishka;Esiovwa, Regina;Connolly, John;Hursthouse, Andrew;Henriquez, Fiona
通讯作者：
Henriquez, Fiona

Genes of past, present and future: does legacy pollution contribute to antibiotic resistance in industrialised estuaries?

过去、现在和未来的基因：遗留污染是否会导致工业化河口的抗生素耐药性？