CORTICAL PLASTICITY--LEARNING ORIGINS OF HUMAN DISABILITY
皮质可塑性--学习人类残疾的起源
基本信息
- 批准号:6243881
- 负责人:
- 金额:$ 13.76万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1997
- 资助国家:美国
- 起止时间:1997-05-15 至 1998-04-30
- 项目状态:已结题
- 来源:
- 关键词:Aotus behavior test behavioral /social science research tag cerebral cortex chordate locomotion computer data analysis disease /disorder model dystonia electrophysiology experience learning method development motor cortex nervous system disorder neural information processing neural plasticity neuroanatomy psychomotor function sensorimotor system sensory cortex tendon injury
项目摘要
An overall objective of our research is to create a foundation
science for understanding the contributions of cortical plasticity
and learning to the origins of, and the expressions of human
neurological disability, and to use that new understanding to guide
remediation therapies. In this project, we shall study cortical
plastic changes induced by repetitive, stereotyped, cognitively
important movement exercises generating coincident afferent
inputs that degrade the cortical representations of muscle and skin
afferent information in the cortex. We shall further document the
neurology of emergent repetitive strain injuries (RSI) including
focal dystonias of the hand (Fdh) generated by this behavioral
training, and relate training-generated de-differentiation of brain
representations of movements and feedback sensory information
controlling movements to the progression of sensorimotor
dysfunction. We shall define the relationship of experience-
induced changes in SI and MI to the onset and progression of pain
and inflammation in the arm, and determine whether or not pain
onset a) enables or amplifies, or b) could be triggered by dynamic,
parralel cortical representational degradation. We shall determine
whether induced plastic changes in motor and sensory cortical
fields are posturally specific, which is signature feature of emergent
focal dystonias. We shall determine whether or not and how
postural strain might contribute to RSI/FDh genesis. Finally, we
shall evaluate remediation training strategies in this primate model,
to access behavioral strategies for redifferentiating cortical
representations of sensory afferents and movements that have been
degraded by RSI/FDh-inducing behaviors.
This study should lead to a fundamental change in how we view
cortical plasticity and learning contributions to chronic neurological
disease, and could have a major impact on the development of
more effective remediation therapies for this very large and
growing patient group.
我们研究的总体目标是建立一个基础
项目成果
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MICHAEL M MERZENICH其他文献
MICHAEL M MERZENICH的其他文献
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{{ truncateString('MICHAEL M MERZENICH', 18)}}的其他基金
Models of catastrophic cortical plasticity contributing
灾难性皮质可塑性贡献模型
- 批准号:
6663430 - 财政年份:2002
- 资助金额:
$ 13.76万 - 项目类别:
Models of catastrophic cortical plasticity contributing
灾难性皮质可塑性贡献模型
- 批准号:
6588521 - 财政年份:2002
- 资助金额:
$ 13.76万 - 项目类别:
CORTICAL PLASTICITY--LEARNING ORIGINS OF HUMAN DISABILITY
皮质可塑性--学习人类残疾的起源
- 批准号:
6449802 - 财政年份:2001
- 资助金额:
$ 13.76万 - 项目类别:
CORTICAL PLASTICITY--LEARNING ORIGINS OF HUMAN DISABILITY
皮质可塑性--学习人类残疾的起源
- 批准号:
6323425 - 财政年份:2000
- 资助金额:
$ 13.76万 - 项目类别:
CORTICAL PLASTICITY--LEARNING ORIGINS OF HUMAN DISABILITY
皮质可塑性--学习人类残疾的起源
- 批准号:
6314151 - 财政年份:2000
- 资助金额:
$ 13.76万 - 项目类别:
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