NEUROBEHAVIORAL EFFECTS OF PARTIAL SLEEP DEPRIVATION

部分睡眠剥夺对神经行为的影响

• 批准号: 6244477
• 负责人: DAVID F DINGES
• 金额: $ 2.36万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-17 至 1998-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6244477
• 关键词: clinical research; cognition; human subject; mood disorders; neuropsychological tests; performance; psychobiology; sleep deprivation; wakefulness

This project seeks to determine how waking neurobehavioral functions (sleep propensity, cognitive performance, sleepiness, and mood) are affected by partial sleep deprivation (PSD). PSD has been identified as a serious public health problem being experienced daily by millions of people as a result of medical, psychiatric, and sleep disorders, as well as social demands (work, family, travel). Although highly prevalent, little scientific work has been done on the nightly duration of sleep and number of days of PSD that will lead to daytime sleepiness, involuntary sleep episodes, performance failures--information that is essential to determining the level of PSD that could result in accidents (e.g., motor vehicle). In a preliminary study, we developed a protocol for studying PSD and demonstrated the sensitivity of a set of neurobehavioral measures to sleep restriction over 1 week. Utilizing this approach, a parametric experiment using independent groups was proposed to test the effects on waking function of the types of sleep restriction most commonly experienced by people. Therefore, the purpose of this study is to determine the nature of the cumulative waking changes in neurobehavioral functions engendered by restricting nocturnal sleep to 4.0 hrs, 6.0 hrs, and 8.0 hrs (control) per night for 14 consecutive nights. Following a 7-14 day period at home, during which time the subjects will be monitored to ensure they have a stable sleep/wake cycle, subjects will live in the Inpatient Study Unit of the CRC for 20 consecutive days, during which time their sleep and waking neurobehavioral functions will be monitored. Following 3 baseline days of 8-10 hr sleep/night, subjects will be randomly assigned to one of three sleep restriction conditions (4,6,8 hr/night) for the next 14 days, followed by 3 days of recovery sleep (8 hr/night).

这个项目旨在确定清醒时的神经行为功能 （睡眠倾向、认知表现、嗜睡和情绪） 部分睡眠剥夺（PSD）。私营部门司被确定为 每天都有数百万人面临严重的公共卫生问题， 人们由于医疗，精神病和睡眠障碍，以及 社会需求（工作、家庭、旅行）。虽然非常普遍， 关于夜间睡眠时间的科学研究很少， PSD的天数，将导致白天嗜睡，非自愿 睡眠发作，表现失败--这些信息对于 确定可能导致事故的PSD水平（例如，电机 车辆）。 在一项初步研究中，我们开发了一种研究方案， PSD，并证明了一套神经行为措施的敏感性 睡眠限制超过一周。 利用这种方法，参数 使用独立组的实验被提出来测试对 最常见的睡眠限制类型的唤醒功能 人们经历过的。 因此，本研究的目的是 确定神经行为的累积清醒变化的性质 通过限制夜间睡眠4.0小时，6.0小时， 和8.0小时（对照）每晚连续14个晚上。 后 7-14在家中的一天，在此期间将对受试者进行监测 为了确保他们有一个稳定的睡眠/觉醒周期，受试者将生活在 CRC的住院研究单位连续20天，在此期间， 将监测他们的睡眠和清醒神经行为功能。 在3天8-10小时睡眠/夜的基线后，受试者将 随机分配到三个睡眠限制条件之一（4，6，8 小时/夜），然后是3天的恢复睡眠（8 小时/夜）。